FDG-PET in differentiating lymphoma from nonmalignant central nervous system lesions in patients with AIDS

J. M. Hoffman; H. A. Waskin; T. Schifter; M. W. Hanson; L. Gray; S. Rosenfeld; R. E. Coleman

FDG-PET in differentiating lymphoma from nonmalignant central nervous system lesions in patients with AIDS

J. M. Hoffman, H. A. Waskin, T. Schifter, M. W. Hanson, L. Gray, S. Rosenfeld, R. E. Coleman

Hematology / Oncology / Cancer Center / Breast Clinic

Research output: Contribution to journal › Article › peer-review

219 Scopus citations

Abstract

Structural imaging studies such as CT or MRI are not able to accurately differentiate infectious from malignant cerebral lesions in patients with AIDS. We studied 11 individuals with AIDS and central nervous system (CNS) lesions with ¹⁸F-fluoro-2-deoxyglucose (FDG) and positron emission tomography (PET). FDG-PET was able to accurately differentiate between a malignant (lymphoma) and nonmalignant etiology for the CNS lesions. Both qualitative visual inspection of the images as well as semiquantitative analysis using count ratios was performed and revealed similar results. FDG- PET may be useful in the management of AIDS patients with CNS lesions since high FDG uptake most likely represents a malignant process which should be biopsied for confirmation rather than treated presumptively as infectious.

Original language	English (US)
Pages (from-to)	567-575
Number of pages	9
Journal	Journal of Nuclear Medicine
Volume	34
Issue number	4
State	Published - 1993

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

Cite this

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title = "FDG-PET in differentiating lymphoma from nonmalignant central nervous system lesions in patients with AIDS",

abstract = "Structural imaging studies such as CT or MRI are not able to accurately differentiate infectious from malignant cerebral lesions in patients with AIDS. We studied 11 individuals with AIDS and central nervous system (CNS) lesions with 18F-fluoro-2-deoxyglucose (FDG) and positron emission tomography (PET). FDG-PET was able to accurately differentiate between a malignant (lymphoma) and nonmalignant etiology for the CNS lesions. Both qualitative visual inspection of the images as well as semiquantitative analysis using count ratios was performed and revealed similar results. FDG- PET may be useful in the management of AIDS patients with CNS lesions since high FDG uptake most likely represents a malignant process which should be biopsied for confirmation rather than treated presumptively as infectious.",

author = "Hoffman, {J. M.} and Waskin, {H. A.} and T. Schifter and Hanson, {M. W.} and L. Gray and S. Rosenfeld and Coleman, {R. E.}",

year = "1993",

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T1 - FDG-PET in differentiating lymphoma from nonmalignant central nervous system lesions in patients with AIDS

AU - Hoffman, J. M.

AU - Waskin, H. A.

AU - Schifter, T.

AU - Hanson, M. W.

AU - Gray, L.

AU - Rosenfeld, S.

AU - Coleman, R. E.

PY - 1993

Y1 - 1993

N2 - Structural imaging studies such as CT or MRI are not able to accurately differentiate infectious from malignant cerebral lesions in patients with AIDS. We studied 11 individuals with AIDS and central nervous system (CNS) lesions with 18F-fluoro-2-deoxyglucose (FDG) and positron emission tomography (PET). FDG-PET was able to accurately differentiate between a malignant (lymphoma) and nonmalignant etiology for the CNS lesions. Both qualitative visual inspection of the images as well as semiquantitative analysis using count ratios was performed and revealed similar results. FDG- PET may be useful in the management of AIDS patients with CNS lesions since high FDG uptake most likely represents a malignant process which should be biopsied for confirmation rather than treated presumptively as infectious.

AB - Structural imaging studies such as CT or MRI are not able to accurately differentiate infectious from malignant cerebral lesions in patients with AIDS. We studied 11 individuals with AIDS and central nervous system (CNS) lesions with 18F-fluoro-2-deoxyglucose (FDG) and positron emission tomography (PET). FDG-PET was able to accurately differentiate between a malignant (lymphoma) and nonmalignant etiology for the CNS lesions. Both qualitative visual inspection of the images as well as semiquantitative analysis using count ratios was performed and revealed similar results. FDG- PET may be useful in the management of AIDS patients with CNS lesions since high FDG uptake most likely represents a malignant process which should be biopsied for confirmation rather than treated presumptively as infectious.

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FDG-PET in differentiating lymphoma from nonmalignant central nervous system lesions in patients with AIDS

Abstract

ASJC Scopus subject areas

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