FDG-PET and CT in evaluation of chemotherapy in advanced head and neck cancer

Thomas A. Dalsaso, Val Lowe, Frank R. Dunphy, David S. Martin, James H. Boyd, Brendan C. Stack

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Purpose: To compare [18F]2-deoxy-2-fluoro-D-glucose-positron emission tomography (FDG-PET) and computed tomography (CT) scans in assessment of response to neoadjuvant chemotherapy in advanced head and neck cancer. Materials and Methods: In a prospective clinical study, advanced head and neck cancer patients were enrolled in a neoadjuvant organ preservation protocol and received CT and FDG-PET scans prior to and after 2 or 3 rounds of chemotherapy. All patients had prechemotherapy and postchemotherapy tissue biopsies within the tumor region. Patients were then classified as pathologic complete response (PCR) or residual disease (RD) based on biopsies. Analysis of the tumor activity, using FDG-PET, was performed using standardized uptake ratios (SUR) in the region of the primary tumor. Analysis of the tumor size, using contrast enhanced CT, was performed using measurements of the primary tumor in 3 dimensions. Results: Nineteen of the 28 patients with stage III and IV cancer of the head and neck enrolled between December 1994 and May 1996 completed the study. Three patients were PCR and had a mean SUR reduction of 82% by positron emission tomography (PET) and volume reduction of 80% by CT. Sixteen patients had RD after chemotherapy, their SUR and volume reductions were 32% and 41%, respectively. Reduction in SUR with PET was significant (P = 0.01). The mean tumor volume reduction by CT approached statistical significance (P = 0.09). There was a positive correlation between the percent reduction in tumor volume and SUR (P < 0.004). Conclusion: FDG-PET and CT imaging are at least equivalent in correctly assessing tumor response to chemotherapy with a trend toward better performance by PET.

Original languageEnglish (US)
Pages (from-to)1-5
Number of pages5
JournalClinical Positron Imaging (Netherlands)
Volume3
Issue number1
DOIs
StatePublished - 2000

Fingerprint

Fluorodeoxyglucose F18
Head and Neck Neoplasms
Positron-Emission Tomography
Drug Therapy
Neoplasms
Tomography
Tumor Burden
Organ Preservation
Biopsy
Cone-Beam Computed Tomography
Positron Emission Tomography Computed Tomography
Prospective Studies

Keywords

  • Chemotherapy
  • Comparative Studies
  • Computed Tomography (CT)
  • Emission CT (ECT)
  • Head and Neck Neoplasms

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

FDG-PET and CT in evaluation of chemotherapy in advanced head and neck cancer. / Dalsaso, Thomas A.; Lowe, Val; Dunphy, Frank R.; Martin, David S.; Boyd, James H.; Stack, Brendan C.

In: Clinical Positron Imaging (Netherlands), Vol. 3, No. 1, 2000, p. 1-5.

Research output: Contribution to journalArticle

Dalsaso, Thomas A. ; Lowe, Val ; Dunphy, Frank R. ; Martin, David S. ; Boyd, James H. ; Stack, Brendan C. / FDG-PET and CT in evaluation of chemotherapy in advanced head and neck cancer. In: Clinical Positron Imaging (Netherlands). 2000 ; Vol. 3, No. 1. pp. 1-5.
@article{463cbbcf0ada42ceacbf05c64a6c8689,
title = "FDG-PET and CT in evaluation of chemotherapy in advanced head and neck cancer",
abstract = "Purpose: To compare [18F]2-deoxy-2-fluoro-D-glucose-positron emission tomography (FDG-PET) and computed tomography (CT) scans in assessment of response to neoadjuvant chemotherapy in advanced head and neck cancer. Materials and Methods: In a prospective clinical study, advanced head and neck cancer patients were enrolled in a neoadjuvant organ preservation protocol and received CT and FDG-PET scans prior to and after 2 or 3 rounds of chemotherapy. All patients had prechemotherapy and postchemotherapy tissue biopsies within the tumor region. Patients were then classified as pathologic complete response (PCR) or residual disease (RD) based on biopsies. Analysis of the tumor activity, using FDG-PET, was performed using standardized uptake ratios (SUR) in the region of the primary tumor. Analysis of the tumor size, using contrast enhanced CT, was performed using measurements of the primary tumor in 3 dimensions. Results: Nineteen of the 28 patients with stage III and IV cancer of the head and neck enrolled between December 1994 and May 1996 completed the study. Three patients were PCR and had a mean SUR reduction of 82{\%} by positron emission tomography (PET) and volume reduction of 80{\%} by CT. Sixteen patients had RD after chemotherapy, their SUR and volume reductions were 32{\%} and 41{\%}, respectively. Reduction in SUR with PET was significant (P = 0.01). The mean tumor volume reduction by CT approached statistical significance (P = 0.09). There was a positive correlation between the percent reduction in tumor volume and SUR (P < 0.004). Conclusion: FDG-PET and CT imaging are at least equivalent in correctly assessing tumor response to chemotherapy with a trend toward better performance by PET.",
keywords = "Chemotherapy, Comparative Studies, Computed Tomography (CT), Emission CT (ECT), Head and Neck Neoplasms",
author = "Dalsaso, {Thomas A.} and Val Lowe and Dunphy, {Frank R.} and Martin, {David S.} and Boyd, {James H.} and Stack, {Brendan C.}",
year = "2000",
doi = "10.1016/S1095-0397(99)00074-6",
language = "English (US)",
volume = "3",
pages = "1--5",
journal = "Molecular Imaging and Biology",
issn = "1536-1632",
publisher = "Springer New York",
number = "1",

}

TY - JOUR

T1 - FDG-PET and CT in evaluation of chemotherapy in advanced head and neck cancer

AU - Dalsaso, Thomas A.

AU - Lowe, Val

AU - Dunphy, Frank R.

AU - Martin, David S.

AU - Boyd, James H.

AU - Stack, Brendan C.

PY - 2000

Y1 - 2000

N2 - Purpose: To compare [18F]2-deoxy-2-fluoro-D-glucose-positron emission tomography (FDG-PET) and computed tomography (CT) scans in assessment of response to neoadjuvant chemotherapy in advanced head and neck cancer. Materials and Methods: In a prospective clinical study, advanced head and neck cancer patients were enrolled in a neoadjuvant organ preservation protocol and received CT and FDG-PET scans prior to and after 2 or 3 rounds of chemotherapy. All patients had prechemotherapy and postchemotherapy tissue biopsies within the tumor region. Patients were then classified as pathologic complete response (PCR) or residual disease (RD) based on biopsies. Analysis of the tumor activity, using FDG-PET, was performed using standardized uptake ratios (SUR) in the region of the primary tumor. Analysis of the tumor size, using contrast enhanced CT, was performed using measurements of the primary tumor in 3 dimensions. Results: Nineteen of the 28 patients with stage III and IV cancer of the head and neck enrolled between December 1994 and May 1996 completed the study. Three patients were PCR and had a mean SUR reduction of 82% by positron emission tomography (PET) and volume reduction of 80% by CT. Sixteen patients had RD after chemotherapy, their SUR and volume reductions were 32% and 41%, respectively. Reduction in SUR with PET was significant (P = 0.01). The mean tumor volume reduction by CT approached statistical significance (P = 0.09). There was a positive correlation between the percent reduction in tumor volume and SUR (P < 0.004). Conclusion: FDG-PET and CT imaging are at least equivalent in correctly assessing tumor response to chemotherapy with a trend toward better performance by PET.

AB - Purpose: To compare [18F]2-deoxy-2-fluoro-D-glucose-positron emission tomography (FDG-PET) and computed tomography (CT) scans in assessment of response to neoadjuvant chemotherapy in advanced head and neck cancer. Materials and Methods: In a prospective clinical study, advanced head and neck cancer patients were enrolled in a neoadjuvant organ preservation protocol and received CT and FDG-PET scans prior to and after 2 or 3 rounds of chemotherapy. All patients had prechemotherapy and postchemotherapy tissue biopsies within the tumor region. Patients were then classified as pathologic complete response (PCR) or residual disease (RD) based on biopsies. Analysis of the tumor activity, using FDG-PET, was performed using standardized uptake ratios (SUR) in the region of the primary tumor. Analysis of the tumor size, using contrast enhanced CT, was performed using measurements of the primary tumor in 3 dimensions. Results: Nineteen of the 28 patients with stage III and IV cancer of the head and neck enrolled between December 1994 and May 1996 completed the study. Three patients were PCR and had a mean SUR reduction of 82% by positron emission tomography (PET) and volume reduction of 80% by CT. Sixteen patients had RD after chemotherapy, their SUR and volume reductions were 32% and 41%, respectively. Reduction in SUR with PET was significant (P = 0.01). The mean tumor volume reduction by CT approached statistical significance (P = 0.09). There was a positive correlation between the percent reduction in tumor volume and SUR (P < 0.004). Conclusion: FDG-PET and CT imaging are at least equivalent in correctly assessing tumor response to chemotherapy with a trend toward better performance by PET.

KW - Chemotherapy

KW - Comparative Studies

KW - Computed Tomography (CT)

KW - Emission CT (ECT)

KW - Head and Neck Neoplasms

UR - http://www.scopus.com/inward/record.url?scp=0002610876&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0002610876&partnerID=8YFLogxK

U2 - 10.1016/S1095-0397(99)00074-6

DO - 10.1016/S1095-0397(99)00074-6

M3 - Article

AN - SCOPUS:0002610876

VL - 3

SP - 1

EP - 5

JO - Molecular Imaging and Biology

JF - Molecular Imaging and Biology

SN - 1536-1632

IS - 1

ER -