Favorable Impact on Stress-Related Behaviors by Modulating Plasma Butyrylcholinesterase

Stephen Brimijoin; Susannah Tye

doi:10.1007/s10571-017-0523-z

Favorable Impact on Stress-Related Behaviors by Modulating Plasma Butyrylcholinesterase

Stephen Brimijoin, Susannah Tye

Research output: Contribution to journal › Review article › peer-review

4 Scopus citations

Abstract

In the last decade, it has become clear that the neuropeptide “ghrelin” and its principal receptor have a large impact on anxiety and stress. Our recent studies have uncovered a link between plasma butyrylcholinesterase (BChE) and ghrelin. BChE actually turns out to be the key regulator of this peptide. This article reviews our recent work on manipulating ghrelin levels in mouse blood and brain by long term elevation of BChE, leading to sustained decrease of ghrelin. That effect in turn was found to reduce stress-induced aggression in group caged mice. Positive consequences were fewer bite wounds and longer survival times. No adverse effects were observed. Further exploration may pave the way for BChE-based treatment of anxiety in humans.

Original language	English (US)
Pages (from-to)	7-12
Number of pages	6
Journal	Cellular and molecular neurobiology
Volume	38
Issue number	1
DOIs	https://doi.org/10.1007/s10571-017-0523-z
State	Published - Jan 1 2018

Keywords

Aggression
Anxiety
Butyrylcholinesterase
Ghrelin
Long term reduction of stress hormone
Mouse models
Stress disorders
Viral gene transfer

ASJC Scopus subject areas

Cellular and Molecular Neuroscience
Cell Biology

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10.1007/s10571-017-0523-z

Cite this

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title = "Favorable Impact on Stress-Related Behaviors by Modulating Plasma Butyrylcholinesterase",

abstract = "In the last decade, it has become clear that the neuropeptide “ghrelin” and its principal receptor have a large impact on anxiety and stress. Our recent studies have uncovered a link between plasma butyrylcholinesterase (BChE) and ghrelin. BChE actually turns out to be the key regulator of this peptide. This article reviews our recent work on manipulating ghrelin levels in mouse blood and brain by long term elevation of BChE, leading to sustained decrease of ghrelin. That effect in turn was found to reduce stress-induced aggression in group caged mice. Positive consequences were fewer bite wounds and longer survival times. No adverse effects were observed. Further exploration may pave the way for BChE-based treatment of anxiety in humans.",

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author = "Stephen Brimijoin and Susannah Tye",

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N2 - In the last decade, it has become clear that the neuropeptide “ghrelin” and its principal receptor have a large impact on anxiety and stress. Our recent studies have uncovered a link between plasma butyrylcholinesterase (BChE) and ghrelin. BChE actually turns out to be the key regulator of this peptide. This article reviews our recent work on manipulating ghrelin levels in mouse blood and brain by long term elevation of BChE, leading to sustained decrease of ghrelin. That effect in turn was found to reduce stress-induced aggression in group caged mice. Positive consequences were fewer bite wounds and longer survival times. No adverse effects were observed. Further exploration may pave the way for BChE-based treatment of anxiety in humans.

AB - In the last decade, it has become clear that the neuropeptide “ghrelin” and its principal receptor have a large impact on anxiety and stress. Our recent studies have uncovered a link between plasma butyrylcholinesterase (BChE) and ghrelin. BChE actually turns out to be the key regulator of this peptide. This article reviews our recent work on manipulating ghrelin levels in mouse blood and brain by long term elevation of BChE, leading to sustained decrease of ghrelin. That effect in turn was found to reduce stress-induced aggression in group caged mice. Positive consequences were fewer bite wounds and longer survival times. No adverse effects were observed. Further exploration may pave the way for BChE-based treatment of anxiety in humans.

KW - Aggression

KW - Anxiety

KW - Butyrylcholinesterase

KW - Ghrelin

KW - Long term reduction of stress hormone

KW - Mouse models

KW - Stress disorders

KW - Viral gene transfer

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Favorable Impact on Stress-Related Behaviors by Modulating Plasma Butyrylcholinesterase

Abstract

Keywords

ASJC Scopus subject areas

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