Favorable Impact on Stress-Related Behaviors by Modulating Plasma Butyrylcholinesterase

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

In the last decade, it has become clear that the neuropeptide “ghrelin” and its principal receptor have a large impact on anxiety and stress. Our recent studies have uncovered a link between plasma butyrylcholinesterase (BChE) and ghrelin. BChE actually turns out to be the key regulator of this peptide. This article reviews our recent work on manipulating ghrelin levels in mouse blood and brain by long term elevation of BChE, leading to sustained decrease of ghrelin. That effect in turn was found to reduce stress-induced aggression in group caged mice. Positive consequences were fewer bite wounds and longer survival times. No adverse effects were observed. Further exploration may pave the way for BChE-based treatment of anxiety in humans.

Original languageEnglish (US)
Pages (from-to)1-6
Number of pages6
JournalCellular and Molecular Neurobiology
DOIs
StateAccepted/In press - Jul 15 2017

Fingerprint

Butyrylcholinesterase
Ghrelin
Anxiety
Bites and Stings
Neuropeptides
Aggression
Peptides
Survival
Wounds and Injuries
Brain

Keywords

  • Aggression
  • Anxiety
  • Butyrylcholinesterase
  • Ghrelin
  • Long term reduction of stress hormone
  • Mouse models
  • Stress disorders
  • Viral gene transfer

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Cell Biology

Cite this

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abstract = "In the last decade, it has become clear that the neuropeptide “ghrelin” and its principal receptor have a large impact on anxiety and stress. Our recent studies have uncovered a link between plasma butyrylcholinesterase (BChE) and ghrelin. BChE actually turns out to be the key regulator of this peptide. This article reviews our recent work on manipulating ghrelin levels in mouse blood and brain by long term elevation of BChE, leading to sustained decrease of ghrelin. That effect in turn was found to reduce stress-induced aggression in group caged mice. Positive consequences were fewer bite wounds and longer survival times. No adverse effects were observed. Further exploration may pave the way for BChE-based treatment of anxiety in humans.",
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