Abstract
There is a renewed interest in the ultimate role of fatty acid synthase (FASN) - a key lipogenic enzyme catalysing the terminal steps in the de novo biogenesis of fatty acids - in cancer pathogenesis. Tumour-associated FASN, by conferring growth and survival advantages rather than functioning as an anabolic energy-storage pathway, appears to necessarily accompany the natural history of most human cancers. A recent identification of cross-talk between FASN and well-established cancer-controlling networks begins to delineate the oncogenic nature of FASN-driven lipogenesis. FASN, a nearly-universal druggable target in many human carcinomas and their precursor lesions, offers new therapeutic opportunities for metabolically treating and preventing cancer.
Original language | English (US) |
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Pages (from-to) | 763-777 |
Number of pages | 15 |
Journal | Nature Reviews Cancer |
Volume | 7 |
Issue number | 10 |
DOIs | |
State | Published - Oct 2007 |
ASJC Scopus subject areas
- Oncology
- Cancer Research