Fatigue in patients with Behcet's syndrome: Relationship with quality of life, depression, anxiety, disability and disease activity

Birkan Ilhan, Meryem Can, Fatma Alibaz-Oner, Sibel Yilmaz-Oner, Ozge Polat-Korkmaz, Gulsen Ozen, Gonca Mumcu, Hilal D Maradit Kremers, Haner Direskeneli

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Objectives: Fatigue is a common symptom of chronic inflammatory diseases. The objective of this study was to investigate fatigue in patients with Behcet's syndrome (BS) and to examine the relationship between fatigue and disease activity, quality of life, anxiety and depression. Methods: This is a cross-sectional study of 123 BS patients and 71 healthy controls in Turkey. All subjects completed the Multidimensional Assessment of Fatigue (MAF) questionnaire, Short form-36 (SF-36), Hospital Anxiety and Depression (HADS) scale and Health Assessment Questionnaire (HAQ). Disease activity among BS patients was assessed using the Behcet Syndrome Activity Scale (BSAS) and the physician's global assessment (PGA). Results: BS patients had significantly higher MAF, HADS-depression (HADS-D) and HADS-anxiety (HADS-A) scores than the healthy controls (P <0.001). Both the physical and mental components of the SF-36 scale were impaired in BS patients (P = 0.0001). BS patients with active disease, depression and anxiety had significantly higher MAF scores compared to BS patients without active disease, depression and anxiety (P = 0.0001). MAF scores showed positive correlations with HADS-A, HADS-D, HAQ scores and negative correlations with SF-36 mental and physical components. In regression analyses, depression, anxiety and physical dysfunction were significantly associated with fatigue, after adjusting for age, sex, SF-36 physical and mental scores, HAQ, HADS-A, HADS-D and BSAS scores (P <0.05). Decreases in SF-36 physical and mental scores were significant predictive factors for high MAF score in healthy controls (P <0.05). Conclusions: Fatigue is common in clinically active BS patients compared with healthy controls and inactive BS patients. Depression, anxiety and physical dysfunction were significantly associated with fatigue.

Original languageEnglish (US)
JournalInternational Journal of Rheumatic Diseases
DOIs
StateAccepted/In press - 2016

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Behcet Syndrome
Fatigue
Anxiety
Quality of Life
Depression
Health
Turkey
Mental Health

Keywords

  • Miscellaneous topics
  • Vasculitides

ASJC Scopus subject areas

  • Rheumatology

Cite this

Fatigue in patients with Behcet's syndrome : Relationship with quality of life, depression, anxiety, disability and disease activity. / Ilhan, Birkan; Can, Meryem; Alibaz-Oner, Fatma; Yilmaz-Oner, Sibel; Polat-Korkmaz, Ozge; Ozen, Gulsen; Mumcu, Gonca; Maradit Kremers, Hilal D; Direskeneli, Haner.

In: International Journal of Rheumatic Diseases, 2016.

Research output: Contribution to journalArticle

Ilhan, Birkan ; Can, Meryem ; Alibaz-Oner, Fatma ; Yilmaz-Oner, Sibel ; Polat-Korkmaz, Ozge ; Ozen, Gulsen ; Mumcu, Gonca ; Maradit Kremers, Hilal D ; Direskeneli, Haner. / Fatigue in patients with Behcet's syndrome : Relationship with quality of life, depression, anxiety, disability and disease activity. In: International Journal of Rheumatic Diseases. 2016.
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title = "Fatigue in patients with Behcet's syndrome: Relationship with quality of life, depression, anxiety, disability and disease activity",
abstract = "Objectives: Fatigue is a common symptom of chronic inflammatory diseases. The objective of this study was to investigate fatigue in patients with Behcet's syndrome (BS) and to examine the relationship between fatigue and disease activity, quality of life, anxiety and depression. Methods: This is a cross-sectional study of 123 BS patients and 71 healthy controls in Turkey. All subjects completed the Multidimensional Assessment of Fatigue (MAF) questionnaire, Short form-36 (SF-36), Hospital Anxiety and Depression (HADS) scale and Health Assessment Questionnaire (HAQ). Disease activity among BS patients was assessed using the Behcet Syndrome Activity Scale (BSAS) and the physician's global assessment (PGA). Results: BS patients had significantly higher MAF, HADS-depression (HADS-D) and HADS-anxiety (HADS-A) scores than the healthy controls (P <0.001). Both the physical and mental components of the SF-36 scale were impaired in BS patients (P = 0.0001). BS patients with active disease, depression and anxiety had significantly higher MAF scores compared to BS patients without active disease, depression and anxiety (P = 0.0001). MAF scores showed positive correlations with HADS-A, HADS-D, HAQ scores and negative correlations with SF-36 mental and physical components. In regression analyses, depression, anxiety and physical dysfunction were significantly associated with fatigue, after adjusting for age, sex, SF-36 physical and mental scores, HAQ, HADS-A, HADS-D and BSAS scores (P <0.05). Decreases in SF-36 physical and mental scores were significant predictive factors for high MAF score in healthy controls (P <0.05). Conclusions: Fatigue is common in clinically active BS patients compared with healthy controls and inactive BS patients. Depression, anxiety and physical dysfunction were significantly associated with fatigue.",
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author = "Birkan Ilhan and Meryem Can and Fatma Alibaz-Oner and Sibel Yilmaz-Oner and Ozge Polat-Korkmaz and Gulsen Ozen and Gonca Mumcu and {Maradit Kremers}, {Hilal D} and Haner Direskeneli",
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T2 - Relationship with quality of life, depression, anxiety, disability and disease activity

AU - Ilhan, Birkan

AU - Can, Meryem

AU - Alibaz-Oner, Fatma

AU - Yilmaz-Oner, Sibel

AU - Polat-Korkmaz, Ozge

AU - Ozen, Gulsen

AU - Mumcu, Gonca

AU - Maradit Kremers, Hilal D

AU - Direskeneli, Haner

PY - 2016

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N2 - Objectives: Fatigue is a common symptom of chronic inflammatory diseases. The objective of this study was to investigate fatigue in patients with Behcet's syndrome (BS) and to examine the relationship between fatigue and disease activity, quality of life, anxiety and depression. Methods: This is a cross-sectional study of 123 BS patients and 71 healthy controls in Turkey. All subjects completed the Multidimensional Assessment of Fatigue (MAF) questionnaire, Short form-36 (SF-36), Hospital Anxiety and Depression (HADS) scale and Health Assessment Questionnaire (HAQ). Disease activity among BS patients was assessed using the Behcet Syndrome Activity Scale (BSAS) and the physician's global assessment (PGA). Results: BS patients had significantly higher MAF, HADS-depression (HADS-D) and HADS-anxiety (HADS-A) scores than the healthy controls (P <0.001). Both the physical and mental components of the SF-36 scale were impaired in BS patients (P = 0.0001). BS patients with active disease, depression and anxiety had significantly higher MAF scores compared to BS patients without active disease, depression and anxiety (P = 0.0001). MAF scores showed positive correlations with HADS-A, HADS-D, HAQ scores and negative correlations with SF-36 mental and physical components. In regression analyses, depression, anxiety and physical dysfunction were significantly associated with fatigue, after adjusting for age, sex, SF-36 physical and mental scores, HAQ, HADS-A, HADS-D and BSAS scores (P <0.05). Decreases in SF-36 physical and mental scores were significant predictive factors for high MAF score in healthy controls (P <0.05). Conclusions: Fatigue is common in clinically active BS patients compared with healthy controls and inactive BS patients. Depression, anxiety and physical dysfunction were significantly associated with fatigue.

AB - Objectives: Fatigue is a common symptom of chronic inflammatory diseases. The objective of this study was to investigate fatigue in patients with Behcet's syndrome (BS) and to examine the relationship between fatigue and disease activity, quality of life, anxiety and depression. Methods: This is a cross-sectional study of 123 BS patients and 71 healthy controls in Turkey. All subjects completed the Multidimensional Assessment of Fatigue (MAF) questionnaire, Short form-36 (SF-36), Hospital Anxiety and Depression (HADS) scale and Health Assessment Questionnaire (HAQ). Disease activity among BS patients was assessed using the Behcet Syndrome Activity Scale (BSAS) and the physician's global assessment (PGA). Results: BS patients had significantly higher MAF, HADS-depression (HADS-D) and HADS-anxiety (HADS-A) scores than the healthy controls (P <0.001). Both the physical and mental components of the SF-36 scale were impaired in BS patients (P = 0.0001). BS patients with active disease, depression and anxiety had significantly higher MAF scores compared to BS patients without active disease, depression and anxiety (P = 0.0001). MAF scores showed positive correlations with HADS-A, HADS-D, HAQ scores and negative correlations with SF-36 mental and physical components. In regression analyses, depression, anxiety and physical dysfunction were significantly associated with fatigue, after adjusting for age, sex, SF-36 physical and mental scores, HAQ, HADS-A, HADS-D and BSAS scores (P <0.05). Decreases in SF-36 physical and mental scores were significant predictive factors for high MAF score in healthy controls (P <0.05). Conclusions: Fatigue is common in clinically active BS patients compared with healthy controls and inactive BS patients. Depression, anxiety and physical dysfunction were significantly associated with fatigue.

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