Fatigue at the neuromuscular junction: Branch point vs. presynaptic vs. postsynaptic mechanisms

Gary C Sieck, Y.s. Prakash

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

There are several pre- and postsynaptic sites where neuromuscular transmission failure (NTF) can occur, leading to peripheral muscle fatigue. Presynaptic sites of NTF include: axonal branch point conduction block; a failure of excitation-secretion coupling at the presynaptic terminal; reductions in quantal release of ACh; and reductions in quantal size. Postsynaptic sites of NTF include; cholinergic receptor desensitization; and reduced sarcolemmal excitability. Susceptibility to NTF increases with stimulation frequency and is most prevalent in fatigable fast-twitch motor units. In addition, susceptibility to NTF varies with age and with conditions of altered use.

Original languageEnglish (US)
Pages (from-to)83-100
Number of pages18
JournalAdvances in Experimental Medicine and Biology
Volume384
StatePublished - 1995

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Muscle Fatigue
Neuromuscular Junction
Presynaptic Terminals
Cholinergic Receptors
Fatigue
Fatigue of materials
Muscle

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

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AB - There are several pre- and postsynaptic sites where neuromuscular transmission failure (NTF) can occur, leading to peripheral muscle fatigue. Presynaptic sites of NTF include: axonal branch point conduction block; a failure of excitation-secretion coupling at the presynaptic terminal; reductions in quantal release of ACh; and reductions in quantal size. Postsynaptic sites of NTF include; cholinergic receptor desensitization; and reduced sarcolemmal excitability. Susceptibility to NTF increases with stimulation frequency and is most prevalent in fatigable fast-twitch motor units. In addition, susceptibility to NTF varies with age and with conditions of altered use.

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