TY - JOUR
T1 - Fatal heart disease among cancer patients
AU - Stoltzfus, Kelsey C.
AU - Zhang, Ying
AU - Sturgeon, Kathleen
AU - Sinoway, Lawrence I.
AU - Trifiletti, Daniel M.
AU - Chinchilli, Vernon M.
AU - Zaorsky, Nicholas G.
N1 - Publisher Copyright:
© 2020, The Author(s).
PY - 2020/12/1
Y1 - 2020/12/1
N2 - As the overlap between heart disease and cancer patients increases as cancer-specific mortality is decreasing and the surviving population is aging, it is necessary to identify cancer patients who are at an increased risk of death from heart disease. The purpose of this study is to identify cancer patients at highest risk of fatal heart disease compared to the general population and other cancer patients at risk of death during the study time period. Here we report that 394,849 of the 7,529,481 cancer patients studied died of heart disease. The heart disease-specific mortality rate is 10.61/10,000-person years, and the standardized mortality ratio (SMR) of fatal heart disease is 2.24 (95% CI: 2.23–2.25). Compared to other cancer patients, patients who are older, male, African American, and unmarried are at a greatest risk of fatal heart disease. For almost all cancer survivors, the risk of fatal heart disease increases with time.
AB - As the overlap between heart disease and cancer patients increases as cancer-specific mortality is decreasing and the surviving population is aging, it is necessary to identify cancer patients who are at an increased risk of death from heart disease. The purpose of this study is to identify cancer patients at highest risk of fatal heart disease compared to the general population and other cancer patients at risk of death during the study time period. Here we report that 394,849 of the 7,529,481 cancer patients studied died of heart disease. The heart disease-specific mortality rate is 10.61/10,000-person years, and the standardized mortality ratio (SMR) of fatal heart disease is 2.24 (95% CI: 2.23–2.25). Compared to other cancer patients, patients who are older, male, African American, and unmarried are at a greatest risk of fatal heart disease. For almost all cancer survivors, the risk of fatal heart disease increases with time.
UR - http://www.scopus.com/inward/record.url?scp=85083834925&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85083834925&partnerID=8YFLogxK
U2 - 10.1038/s41467-020-15639-5
DO - 10.1038/s41467-020-15639-5
M3 - Article
C2 - 32332714
AN - SCOPUS:85083834925
SN - 2041-1723
VL - 11
JO - Nature communications
JF - Nature communications
IS - 1
M1 - 2011
ER -