Fatal Disseminated Aspergillosis following Sequential Heart and Stem Cell Transplantation for Systemic Amyloidosis

Raymund R. Razonable, Robin Patel, Mark P. Wilhelm, Morie A. Gertz, Mark R. Litzow, David J. Inwards, Joseph A. Dearani, Brooks S. Edwards, Christopher G. McGregor

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Infectious complications are a major cause of morbidity and mortality in transplant recipients. We describe a case of fatal disseminated aspergillosis immediately following autologous peripheral stem cell reconstitution in a patient who had undergone orthotopic heart transplantation for systemic amyloidosis. The case described suggests that the infectious risks in patients undergoing these sequential procedures may be distinct from those occurring in patients undergoing either procedure independently. Potential prophylactic and therapeutic interventions are discussed. Since this experimental and evolving approach for the management of systemic amyloidosis is potentially applicable to a limited number of patients, multicenter collaboration may be needed to further define the infectious risks in this unique subset of transplant recipients.

Original languageEnglish (US)
Pages (from-to)93-95
Number of pages3
JournalAmerican Journal of Transplantation
Volume1
Issue number1
DOIs
StatePublished - May 2001

Keywords

  • Amyloidosis
  • Aspergillosis
  • Heart transplant
  • Stem cell transplant

ASJC Scopus subject areas

  • Immunology and Allergy
  • Transplantation
  • Pharmacology (medical)

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