Fat-induced liver insulin resistance

Pankaj Shah, Ananda Basu, Robert Rizza

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

In vitro studies have established that free fatty acids (FFAs) are important regulators of hepatic glucose metabolism. FFAs can increase hepatic glucose release by increasing the amount and activity of glucose-6-phosphatase and multiple gluconeogenic enzymes. Elevated FFAs can also potentially decrease hepatic glucose uptake by decreasing hepatic glucokinase activity. In vivo studies in both animals and humans have shown a close correlation between changes in plasma FFAs and endogenous glucose production (EGP). Intervention studies have established that changes in plasma FFAs are accompanied by changes in the relative contribution of gluconeogenesis and glycogenolysis to EGP. The effects of a change in FFAs on EGP itself are more evident when compensatory changes in insulin secretion are prevented or when insulin secretion is impaired (eg, diabetes mellitus). The effects of elevated FFAs on splanchnic glucose uptake are less clear, in that they appear to have no effect in nondiabetic humans and may impair uptake in people with type 2 diabetes.

Original languageEnglish (US)
Pages (from-to)214-218
Number of pages5
JournalCurrent Diabetes Reports
Volume3
Issue number3
StatePublished - Jun 2003

Fingerprint

Nonesterified Fatty Acids
Insulin Resistance
Fats
Glucose
Liver
Insulin
Glucokinase
Glycogenolysis
Glucose-6-Phosphatase
Gluconeogenesis
Viscera
Type 2 Diabetes Mellitus
Diabetes Mellitus
Enzymes

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Shah, P., Basu, A., & Rizza, R. (2003). Fat-induced liver insulin resistance. Current Diabetes Reports, 3(3), 214-218.

Fat-induced liver insulin resistance. / Shah, Pankaj; Basu, Ananda; Rizza, Robert.

In: Current Diabetes Reports, Vol. 3, No. 3, 06.2003, p. 214-218.

Research output: Contribution to journalArticle

Shah, P, Basu, A & Rizza, R 2003, 'Fat-induced liver insulin resistance', Current Diabetes Reports, vol. 3, no. 3, pp. 214-218.
Shah P, Basu A, Rizza R. Fat-induced liver insulin resistance. Current Diabetes Reports. 2003 Jun;3(3):214-218.
Shah, Pankaj ; Basu, Ananda ; Rizza, Robert. / Fat-induced liver insulin resistance. In: Current Diabetes Reports. 2003 ; Vol. 3, No. 3. pp. 214-218.
@article{cbba9308033f4565b333663769649f97,
title = "Fat-induced liver insulin resistance",
abstract = "In vitro studies have established that free fatty acids (FFAs) are important regulators of hepatic glucose metabolism. FFAs can increase hepatic glucose release by increasing the amount and activity of glucose-6-phosphatase and multiple gluconeogenic enzymes. Elevated FFAs can also potentially decrease hepatic glucose uptake by decreasing hepatic glucokinase activity. In vivo studies in both animals and humans have shown a close correlation between changes in plasma FFAs and endogenous glucose production (EGP). Intervention studies have established that changes in plasma FFAs are accompanied by changes in the relative contribution of gluconeogenesis and glycogenolysis to EGP. The effects of a change in FFAs on EGP itself are more evident when compensatory changes in insulin secretion are prevented or when insulin secretion is impaired (eg, diabetes mellitus). The effects of elevated FFAs on splanchnic glucose uptake are less clear, in that they appear to have no effect in nondiabetic humans and may impair uptake in people with type 2 diabetes.",
author = "Pankaj Shah and Ananda Basu and Robert Rizza",
year = "2003",
month = "6",
language = "English (US)",
volume = "3",
pages = "214--218",
journal = "Current Diabetes Reports",
issn = "1534-4827",
publisher = "Current Medicine Group",
number = "3",

}

TY - JOUR

T1 - Fat-induced liver insulin resistance

AU - Shah, Pankaj

AU - Basu, Ananda

AU - Rizza, Robert

PY - 2003/6

Y1 - 2003/6

N2 - In vitro studies have established that free fatty acids (FFAs) are important regulators of hepatic glucose metabolism. FFAs can increase hepatic glucose release by increasing the amount and activity of glucose-6-phosphatase and multiple gluconeogenic enzymes. Elevated FFAs can also potentially decrease hepatic glucose uptake by decreasing hepatic glucokinase activity. In vivo studies in both animals and humans have shown a close correlation between changes in plasma FFAs and endogenous glucose production (EGP). Intervention studies have established that changes in plasma FFAs are accompanied by changes in the relative contribution of gluconeogenesis and glycogenolysis to EGP. The effects of a change in FFAs on EGP itself are more evident when compensatory changes in insulin secretion are prevented or when insulin secretion is impaired (eg, diabetes mellitus). The effects of elevated FFAs on splanchnic glucose uptake are less clear, in that they appear to have no effect in nondiabetic humans and may impair uptake in people with type 2 diabetes.

AB - In vitro studies have established that free fatty acids (FFAs) are important regulators of hepatic glucose metabolism. FFAs can increase hepatic glucose release by increasing the amount and activity of glucose-6-phosphatase and multiple gluconeogenic enzymes. Elevated FFAs can also potentially decrease hepatic glucose uptake by decreasing hepatic glucokinase activity. In vivo studies in both animals and humans have shown a close correlation between changes in plasma FFAs and endogenous glucose production (EGP). Intervention studies have established that changes in plasma FFAs are accompanied by changes in the relative contribution of gluconeogenesis and glycogenolysis to EGP. The effects of a change in FFAs on EGP itself are more evident when compensatory changes in insulin secretion are prevented or when insulin secretion is impaired (eg, diabetes mellitus). The effects of elevated FFAs on splanchnic glucose uptake are less clear, in that they appear to have no effect in nondiabetic humans and may impair uptake in people with type 2 diabetes.

UR - http://www.scopus.com/inward/record.url?scp=0042521202&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0042521202&partnerID=8YFLogxK

M3 - Article

VL - 3

SP - 214

EP - 218

JO - Current Diabetes Reports

JF - Current Diabetes Reports

SN - 1534-4827

IS - 3

ER -