Fat depots, free fatty acids, and dyslipidemia.

Research output: Contribution to journalArticle

121 Citations (Scopus)

Abstract

Body fat deposition and excess free fatty acid (FFA) metabolism contribute to dyslipidemia and the adverse health consequences of obesity. Individuals with upper body obesity have impaired functioning of adipocytes, the primary fatty acid storage site. Excess visceral fat is strongly associated with impaired suppression of FFA release in response to insulin, as well as with hypertriglyceridemia and low concentrations of high density lipoprotein (HDL) cholesterol. High FFA concentrations can induce insulin resistance in muscle and liver. Furthermore, failure of hyperinsulinemia to normally suppress FFA is associated with impaired carbohydrate oxidation and muscle glucose storage, reduced hepatic insulin clearance and elevated triglycerides. Understanding the impact of body fat distribution on FFA metabolism and dyslipidemia is critical for determining the link between overweight and obesity and cardiovascular disease risk. In the current review, we will explore the relationship between adipose tissue, body fat depots, and FFA metabolism.

Original languageEnglish (US)
Pages (from-to)498-508
Number of pages11
JournalNutrients
Volume5
Issue number2
DOIs
StatePublished - Feb 2013

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hyperlipidemia
Dyslipidemias
Nonesterified Fatty Acids
free fatty acids
Fats
fatty acid metabolism
lipids
Adipose Tissue
obesity
Obesity
body fat
insulin
Insulin
Body Fat Distribution
body fat distribution
Muscles
muscles
hypertriglyceridemia
visceral fat
liver

ASJC Scopus subject areas

  • Food Science

Cite this

Fat depots, free fatty acids, and dyslipidemia. / Ebbert, Jon Owen; Jensen, Michael Dennis.

In: Nutrients, Vol. 5, No. 2, 02.2013, p. 498-508.

Research output: Contribution to journalArticle

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