Fas/FasL

Maria Eugenia Guicciardi, Gregory James Gores

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Fas (also known as CD95) is a prototypical death receptor abundantly expressed in liver cells. Engagement of Fas typically triggers a signaling cascade culminating in cell death by apoptosis. Recent studies, however, have demonstrated that several other cellular responses can be initiated by Fas, including proliferation, migration, inflammation, and necrotic cell death. Alterations in Fas signaling are often associated with liver disease. This chapter reviews the molecular mechanisms and regulation of Fas signaling, and the role of Fas in the pathophysiology of the liver.

Original languageEnglish (US)
Title of host publicationSignaling Pathways in Liver Diseases: Third Edition
PublisherWiley Blackwell
Pages203-213
Number of pages11
ISBN (Print)9781118663387, 9781118663394
DOIs
StatePublished - Sep 28 2015

Keywords

  • Apoptosis
  • Cell death
  • Cell signaling
  • Death receptors
  • Hepatic fibrosis
  • Liver disease
  • Liver physiology

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Guicciardi, M. E., & Gores, G. J. (2015). Fas/FasL. In Signaling Pathways in Liver Diseases: Third Edition (pp. 203-213). Wiley Blackwell. https://doi.org/10.1002/9781118663387.ch15