Fas/FasL

Maria Eugenia Guicciardi, Gregory James Gores

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Fas (CD95, APO-1) belongs to the death receptor family, a subgroup of the tumor necrosis factor/nerve growth factor (TNF/NGF) receptor superfamily. These cell surface cytokine receptors are able to initiate an apoptotic signaling cascade after binding a group of structurally related ligands or specific antibodies [1]. The members of this family are type-I transmembrane proteins with a C-terminal intracellular tail, a membrane spanning region, and an extracellular N-terminal domain. Through interaction with the N-terminal domain, the receptors bind their cognate ligands (called death ligands), the majority of which are type-II transmembrane proteins belonging to the TNF family of proteins and comprised of an intracellular N-terminal domain, a transmembrane region, and a C-terminal extracellular tail. The signature features of the death receptors are represented by a highly homologous region in their extracellular domains containing one to five cysteine-rich domains (CRD) and a ∼80-amino acid cytoplasmic sequence known as death domain (DD), which is required to initiate the death signal.

Original languageEnglish (US)
Title of host publicationSignaling Pathways in Liver Diseases
PublisherSpringer Berlin Heidelberg
Pages179-188
Number of pages10
ISBN (Print)9783642001499
DOIs
StatePublished - 2010

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Death Domain Receptors
Ligands
Nerve Growth Factor Receptor
Proteins
Cytokine Receptors
Cell Surface Receptors
Cysteine
Amino Acid Sequence
Tumor Necrosis Factor-alpha
Membranes
Antibodies
Death Domain

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Guicciardi, M. E., & Gores, G. J. (2010). Fas/FasL. In Signaling Pathways in Liver Diseases (pp. 179-188). Springer Berlin Heidelberg. https://doi.org/10.1007/978-3-642-00150-5_11

Fas/FasL. / Guicciardi, Maria Eugenia; Gores, Gregory James.

Signaling Pathways in Liver Diseases. Springer Berlin Heidelberg, 2010. p. 179-188.

Research output: Chapter in Book/Report/Conference proceedingChapter

Guicciardi, ME & Gores, GJ 2010, Fas/FasL. in Signaling Pathways in Liver Diseases. Springer Berlin Heidelberg, pp. 179-188. https://doi.org/10.1007/978-3-642-00150-5_11
Guicciardi ME, Gores GJ. Fas/FasL. In Signaling Pathways in Liver Diseases. Springer Berlin Heidelberg. 2010. p. 179-188 https://doi.org/10.1007/978-3-642-00150-5_11
Guicciardi, Maria Eugenia ; Gores, Gregory James. / Fas/FasL. Signaling Pathways in Liver Diseases. Springer Berlin Heidelberg, 2010. pp. 179-188
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