Family history of stroke and severity of neurologic deficit after stroke

J. F. Meschia, L. D. Case, B. B. Worrall, R. D. Brown, T. G. Brott, M. Frankel, S. Silliman, S. S. Rich

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

BACKGROUND: A family history of stroke is an independent risk factor for stroke. OBJECTIVE: To assess whether severity of neurologic deficit after stroke is associated with a family history of stroke. METHODS: The Ischemic Stroke Genetics Study, a five-center study of first-ever symptomatic ischemic stroke, assessed case subjects prospectively for a family history of stroke-affected first-degree relatives. Certified adjudicators used the NIH Stroke Scale (NIHSS) to determine the severity of neurologic deficit. RESULTS: A total of 505 case subjects were enrolled (median age, 65 years; 55% male), with 81% enrolled within 1 week of onset of symptoms. A sibling history of stroke was associated with more severe stroke. The odds of an NIHSS score of 5 or higher were 2.0 times greater for cases with a sibling history of stroke compared with cases with no sibling history (95% CI, 1.0 to 3.9). An association of family history of stroke in parents or children with stroke severity was not detected. CONCLUSIONS: A sibling history of stroke increased the likelihood of a more severe stroke in the case subjects, independent of age, sex, and other potential confounding factors. Other family history characteristics were not associated with stroke severity.

Original languageEnglish (US)
Pages (from-to)1396-1402
Number of pages7
JournalNeurology
Volume67
Issue number8
DOIs
StatePublished - Oct 2006

ASJC Scopus subject areas

  • Clinical Neurology

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