TY - JOUR
T1 - Family history of cancer and risk of pancreatic cancer
T2 - A pooled analysis from the Pancreatic Cancer Cohort Consortium (PanScan)
AU - Jacobs, Eric J.
AU - Chanock, Stephen J.
AU - Fuchs, Charles S.
AU - LaCroix, Andrea
AU - McWilliams, Robert R.
AU - Steplowski, Emily
AU - Stolzenberg-Solomon, Rachael Z.
AU - Arslan, Alan A.
AU - Bas Bueno-de-Mesquita, H.
AU - Gross, Myron
AU - Helzlsouer, Kathy
AU - Petersen, Gloria
AU - Zheng, Wei
AU - Agalliu, Ilir
AU - Allen, Naomi E.
AU - Amundadottir, Laufey
AU - Boutron-Ruault, Marie Christine
AU - Buring, Julie E.
AU - Canzian, Federico
AU - Clipp, Sandra
AU - Dorronsoro, Miren
AU - Gaziano, J. Michael
AU - Giovannucci, Edward L.
AU - Hankinson, Susan E.
AU - Hartge, Patricia
AU - Hoover, Robert N.
AU - Hunter, David J.
AU - Jacobs, Kevin B.
AU - Jenab, Mazda
AU - Kraft, Peter
AU - Kooperberg, Charles
AU - Lynch, Shannon M.
AU - Sund, Malin
AU - Mendelsohn, Julie B.
AU - Mouw, Tracy
AU - Newton, Christina C.
AU - Overvad, Kim
AU - Palli, Domenico
AU - Peeters, Petra H.M.
AU - Rajkovic, Aleksandar
AU - Shu, Xiao Ou
AU - Thomas, Gilles
AU - Tobias, Geoffrey S.
AU - Trichopoulos, Dimitrios
AU - Virtamo, Jarmo
AU - Wactawski-Wende, Jean
AU - Wolpin, Brian M.
AU - Yu, Kai
AU - Zeleniuch-Jacquotte, Anne
PY - 2010/9/1
Y1 - 2010/9/1
N2 - A family history of pancreatic cancer has consistently been associated with increased risk of pancreatic cancer. However, uncertainty remains about the strength of this association. Results from previous studies suggest a family history of select cancers (i.e., ovarian, breast and colorectal) could also be associated, although not as strongly, with increased risk of pancreatic cancer. We examined the association between a family history of 5 types of cancer (pancreas, prostate, ovarian, breast and colorectal) and risk of pancreatic cancer using data from a collaborative nested case-control study conducted by the Pancreatic Cancer Cohort Consortium. Cases and controls were from cohort studies from the United States, Europe and China, and a case-control study from the Mayo Clinic. Analyses of family history of pancreatic cancer included 1,183 cases and 1,205 controls. A family history of pancreatic cancer in a parent, sibling or child was associated with increased risk of pancreatic cancer [multivariate-adjusted odds ratios (ORs) = 1.76, 95% confidence interval (CI) = 1.19-2.61]. A family history of prostate cancer was also associated with increased risk (OR = 1.45, 95% CI = 1.12-1.89). There were no statistically significant associations with a family history of ovarian cancer (OR = 0.82, 95% CI = 0.52-1.31), breast cancer (OR = 1.21, 95% CI = 0.97-1.51) or colorectal cancer (OR = 1.17, 95% CI = 0.93-1.47). Our results confirm a moderate sized association between a family history of pancreatic cancer and risk of pancreatic cancer and also provide evidence for an association with a family history of prostate cancer worth further study.
AB - A family history of pancreatic cancer has consistently been associated with increased risk of pancreatic cancer. However, uncertainty remains about the strength of this association. Results from previous studies suggest a family history of select cancers (i.e., ovarian, breast and colorectal) could also be associated, although not as strongly, with increased risk of pancreatic cancer. We examined the association between a family history of 5 types of cancer (pancreas, prostate, ovarian, breast and colorectal) and risk of pancreatic cancer using data from a collaborative nested case-control study conducted by the Pancreatic Cancer Cohort Consortium. Cases and controls were from cohort studies from the United States, Europe and China, and a case-control study from the Mayo Clinic. Analyses of family history of pancreatic cancer included 1,183 cases and 1,205 controls. A family history of pancreatic cancer in a parent, sibling or child was associated with increased risk of pancreatic cancer [multivariate-adjusted odds ratios (ORs) = 1.76, 95% confidence interval (CI) = 1.19-2.61]. A family history of prostate cancer was also associated with increased risk (OR = 1.45, 95% CI = 1.12-1.89). There were no statistically significant associations with a family history of ovarian cancer (OR = 0.82, 95% CI = 0.52-1.31), breast cancer (OR = 1.21, 95% CI = 0.97-1.51) or colorectal cancer (OR = 1.17, 95% CI = 0.93-1.47). Our results confirm a moderate sized association between a family history of pancreatic cancer and risk of pancreatic cancer and also provide evidence for an association with a family history of prostate cancer worth further study.
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U2 - 10.1002/ijc.25148
DO - 10.1002/ijc.25148
M3 - Article
C2 - 20049842
AN - SCOPUS:77955632039
SN - 0020-7136
VL - 127
SP - 1421
EP - 1428
JO - International Journal of Cancer
JF - International Journal of Cancer
IS - 6
ER -