Family History Associates With Increased Risk of Colorectal Cancer in Patients With Inflammatory Bowel Diseases

Niloy Jewel Samadder, John F. Valentine, Stephen Guthery, Harminder Singh, Charles N. Bernstein, Jonathan A Leighton, Yuan Wan, Jathine Wong, Kenneth Boucher, Lisa Pappas, Kerry Rowe, Randall W. Burt, Karen Curtin, Ken R. Smith

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background & Aims: Individuals with inflammatory bowel diseases (IBDs) have an increased risk of developing colorectal cancer (CRC). Although family history of CRC is a well-established risk factor in healthy individuals, its role in patients with IBD is less clear. We aimed to estimate the risk of CRC in a cohort of patients with IBD from Utah and the significance of family history of CRC in a first-degree relative (FDR). Methods: We identified Utah residents with IBD, using the Intermountain Healthcare and University of Utah Health Sciences databases, from January 1, 1996, through December 31, 2011. CRCs were identified using the Utah Cancer Registry and linked to pedigrees from the Utah Population Database. CRC incidence was compared with that of the state population by standardized incidence ratios (SIRs). Results: A cohort of 9505 individuals with IBD was identified and 101 developed CRC during the study period. The SIR for CRC in patients with Crohn's disease was 3.4 (95% CI, 2.3–4.4), and in patients with ulcerative colitis was 5.2 (95% CI, 3.9–6.6). Patients with IBD and a concurrent diagnosis of primary sclerosing cholangitis had the greatest risk of CRC (SIR, 14.8; 95% CI, 8.3–21.2). A history of CRC in a FDR was associated with a nearly 8-fold increase in risk of CRC in patients with IBD (SIR, 7.9; 95% CI, 1.6–14.3), compared with the state population. Conclusions: Patients with IBD have a 3- to 5-fold increase in risk of CRC, and those with CRC in a FDR have an almost 8-fold increase in risk. Family history may act as a simple measure to identify individuals with IBD at highest risk for CRC and indicates the need for enhanced surveillance in this population.

Original languageEnglish (US)
JournalClinical Gastroenterology and Hepatology
DOIs
StatePublished - Jan 1 2019

Fingerprint

Inflammatory Bowel Diseases
Colorectal Neoplasms
Incidence
Population Surveillance
Databases
Population
Sclerosing Cholangitis
Pedigree
Ulcerative Colitis
Crohn Disease
Registries
Delivery of Health Care

Keywords

  • Colitis-Associated Cancer
  • Colon Cancer
  • Genetics
  • PSC
  • SIRs

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

Cite this

Family History Associates With Increased Risk of Colorectal Cancer in Patients With Inflammatory Bowel Diseases. / Samadder, Niloy Jewel; Valentine, John F.; Guthery, Stephen; Singh, Harminder; Bernstein, Charles N.; Leighton, Jonathan A; Wan, Yuan; Wong, Jathine; Boucher, Kenneth; Pappas, Lisa; Rowe, Kerry; Burt, Randall W.; Curtin, Karen; Smith, Ken R.

In: Clinical Gastroenterology and Hepatology, 01.01.2019.

Research output: Contribution to journalArticle

Samadder, NJ, Valentine, JF, Guthery, S, Singh, H, Bernstein, CN, Leighton, JA, Wan, Y, Wong, J, Boucher, K, Pappas, L, Rowe, K, Burt, RW, Curtin, K & Smith, KR 2019, 'Family History Associates With Increased Risk of Colorectal Cancer in Patients With Inflammatory Bowel Diseases', Clinical Gastroenterology and Hepatology. https://doi.org/10.1016/j.cgh.2018.09.038
Samadder, Niloy Jewel ; Valentine, John F. ; Guthery, Stephen ; Singh, Harminder ; Bernstein, Charles N. ; Leighton, Jonathan A ; Wan, Yuan ; Wong, Jathine ; Boucher, Kenneth ; Pappas, Lisa ; Rowe, Kerry ; Burt, Randall W. ; Curtin, Karen ; Smith, Ken R. / Family History Associates With Increased Risk of Colorectal Cancer in Patients With Inflammatory Bowel Diseases. In: Clinical Gastroenterology and Hepatology. 2019.
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abstract = "Background & Aims: Individuals with inflammatory bowel diseases (IBDs) have an increased risk of developing colorectal cancer (CRC). Although family history of CRC is a well-established risk factor in healthy individuals, its role in patients with IBD is less clear. We aimed to estimate the risk of CRC in a cohort of patients with IBD from Utah and the significance of family history of CRC in a first-degree relative (FDR). Methods: We identified Utah residents with IBD, using the Intermountain Healthcare and University of Utah Health Sciences databases, from January 1, 1996, through December 31, 2011. CRCs were identified using the Utah Cancer Registry and linked to pedigrees from the Utah Population Database. CRC incidence was compared with that of the state population by standardized incidence ratios (SIRs). Results: A cohort of 9505 individuals with IBD was identified and 101 developed CRC during the study period. The SIR for CRC in patients with Crohn's disease was 3.4 (95{\%} CI, 2.3–4.4), and in patients with ulcerative colitis was 5.2 (95{\%} CI, 3.9–6.6). Patients with IBD and a concurrent diagnosis of primary sclerosing cholangitis had the greatest risk of CRC (SIR, 14.8; 95{\%} CI, 8.3–21.2). A history of CRC in a FDR was associated with a nearly 8-fold increase in risk of CRC in patients with IBD (SIR, 7.9; 95{\%} CI, 1.6–14.3), compared with the state population. Conclusions: Patients with IBD have a 3- to 5-fold increase in risk of CRC, and those with CRC in a FDR have an almost 8-fold increase in risk. Family history may act as a simple measure to identify individuals with IBD at highest risk for CRC and indicates the need for enhanced surveillance in this population.",
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AU - Samadder, Niloy Jewel

AU - Valentine, John F.

AU - Guthery, Stephen

AU - Singh, Harminder

AU - Bernstein, Charles N.

AU - Leighton, Jonathan A

AU - Wan, Yuan

AU - Wong, Jathine

AU - Boucher, Kenneth

AU - Pappas, Lisa

AU - Rowe, Kerry

AU - Burt, Randall W.

AU - Curtin, Karen

AU - Smith, Ken R.

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N2 - Background & Aims: Individuals with inflammatory bowel diseases (IBDs) have an increased risk of developing colorectal cancer (CRC). Although family history of CRC is a well-established risk factor in healthy individuals, its role in patients with IBD is less clear. We aimed to estimate the risk of CRC in a cohort of patients with IBD from Utah and the significance of family history of CRC in a first-degree relative (FDR). Methods: We identified Utah residents with IBD, using the Intermountain Healthcare and University of Utah Health Sciences databases, from January 1, 1996, through December 31, 2011. CRCs were identified using the Utah Cancer Registry and linked to pedigrees from the Utah Population Database. CRC incidence was compared with that of the state population by standardized incidence ratios (SIRs). Results: A cohort of 9505 individuals with IBD was identified and 101 developed CRC during the study period. The SIR for CRC in patients with Crohn's disease was 3.4 (95% CI, 2.3–4.4), and in patients with ulcerative colitis was 5.2 (95% CI, 3.9–6.6). Patients with IBD and a concurrent diagnosis of primary sclerosing cholangitis had the greatest risk of CRC (SIR, 14.8; 95% CI, 8.3–21.2). A history of CRC in a FDR was associated with a nearly 8-fold increase in risk of CRC in patients with IBD (SIR, 7.9; 95% CI, 1.6–14.3), compared with the state population. Conclusions: Patients with IBD have a 3- to 5-fold increase in risk of CRC, and those with CRC in a FDR have an almost 8-fold increase in risk. Family history may act as a simple measure to identify individuals with IBD at highest risk for CRC and indicates the need for enhanced surveillance in this population.

AB - Background & Aims: Individuals with inflammatory bowel diseases (IBDs) have an increased risk of developing colorectal cancer (CRC). Although family history of CRC is a well-established risk factor in healthy individuals, its role in patients with IBD is less clear. We aimed to estimate the risk of CRC in a cohort of patients with IBD from Utah and the significance of family history of CRC in a first-degree relative (FDR). Methods: We identified Utah residents with IBD, using the Intermountain Healthcare and University of Utah Health Sciences databases, from January 1, 1996, through December 31, 2011. CRCs were identified using the Utah Cancer Registry and linked to pedigrees from the Utah Population Database. CRC incidence was compared with that of the state population by standardized incidence ratios (SIRs). Results: A cohort of 9505 individuals with IBD was identified and 101 developed CRC during the study period. The SIR for CRC in patients with Crohn's disease was 3.4 (95% CI, 2.3–4.4), and in patients with ulcerative colitis was 5.2 (95% CI, 3.9–6.6). Patients with IBD and a concurrent diagnosis of primary sclerosing cholangitis had the greatest risk of CRC (SIR, 14.8; 95% CI, 8.3–21.2). A history of CRC in a FDR was associated with a nearly 8-fold increase in risk of CRC in patients with IBD (SIR, 7.9; 95% CI, 1.6–14.3), compared with the state population. Conclusions: Patients with IBD have a 3- to 5-fold increase in risk of CRC, and those with CRC in a FDR have an almost 8-fold increase in risk. Family history may act as a simple measure to identify individuals with IBD at highest risk for CRC and indicates the need for enhanced surveillance in this population.

KW - Colitis-Associated Cancer

KW - Colon Cancer

KW - Genetics

KW - PSC

KW - SIRs

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