Family history as a risk factor for carotid artery stenosis

Mahyar Khaleghi, Iyad N. Isseh, Hayan Jouni, Sunghwan Sohn, Kent R Bailey, Iftikhar Jan Kullo

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

BACKGROUND AND PURPOSE - : We investigated whether family history of stroke or coronary heart disease (CHD) is associated with presence of carotid artery stenosis (CAS). METHODS - : The study cohort included 864 patients (72±8 years; 68% men) with CAS and 1698 controls (61±11 years; 55% men) referred for noninvasive vascular testing. CAS was defined as ≥70% stenosis in the internal carotid artery on ultrasound or history of carotid revascularization. Controls did not have CAS or history of cerebrovascular disease or CHD. Family history of stroke and CHD was defined as having ≥1 first-degree relative who had stroke or CHD before age 65 years. Logistic regression analysis was used to evaluate whether family history of stroke or CHD was associated with presence of CAS, independent of conventional risk factors. RESULTS - : Family history of stroke and CHD was present more often in patients with CAS than in controls, with a resulting odds ratios (95% confidence interval) of 2.02 (1.61-2.53) and 2.01 (1.70-2.37), respectively. The associations remained significant after adjustment for age, sex, body mass index, smoking, diabetes mellitus, hypertension, and dyslipidemia; odds ratios: 1.41 (1.06-1.90) and 1.69 (1.35-2.10), respectively. A greater number of affected relatives with stroke or CHD was associated with higher odds of CAS; adjusted odds ratios: 1.25 (0.91-1.72) and 1.46 (1.14-1.89) versus 2.65 (1.35-5.40) and 2.13 (1.57-2.90) for patients with 1 and ≥2 affected relatives with stroke and CHD, respectively. CONCLUSIONS - : Family history of stroke, and of CHD were each associated with CAS, suggesting that shared genetic and environmental factors contribute to the risk of CAS.

Original languageEnglish (US)
Pages (from-to)2252-2256
Number of pages5
JournalStroke
Volume45
Issue number8
DOIs
StatePublished - 2014

Fingerprint

Carotid Stenosis
Coronary Disease
Stroke
Odds Ratio
Cerebrovascular Disorders
Dyslipidemias
Blood Vessels
Diabetes Mellitus
Body Mass Index
Cohort Studies
Logistic Models
Smoking
Regression Analysis
Confidence Intervals
Hypertension

Keywords

  • atherosclerosis
  • carotid stenosis
  • coronary heart disease
  • risk factors
  • stroke

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Clinical Neurology
  • Advanced and Specialized Nursing

Cite this

Family history as a risk factor for carotid artery stenosis. / Khaleghi, Mahyar; Isseh, Iyad N.; Jouni, Hayan; Sohn, Sunghwan; Bailey, Kent R; Kullo, Iftikhar Jan.

In: Stroke, Vol. 45, No. 8, 2014, p. 2252-2256.

Research output: Contribution to journalArticle

Khaleghi, Mahyar ; Isseh, Iyad N. ; Jouni, Hayan ; Sohn, Sunghwan ; Bailey, Kent R ; Kullo, Iftikhar Jan. / Family history as a risk factor for carotid artery stenosis. In: Stroke. 2014 ; Vol. 45, No. 8. pp. 2252-2256.
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abstract = "BACKGROUND AND PURPOSE - : We investigated whether family history of stroke or coronary heart disease (CHD) is associated with presence of carotid artery stenosis (CAS). METHODS - : The study cohort included 864 patients (72±8 years; 68{\%} men) with CAS and 1698 controls (61±11 years; 55{\%} men) referred for noninvasive vascular testing. CAS was defined as ≥70{\%} stenosis in the internal carotid artery on ultrasound or history of carotid revascularization. Controls did not have CAS or history of cerebrovascular disease or CHD. Family history of stroke and CHD was defined as having ≥1 first-degree relative who had stroke or CHD before age 65 years. Logistic regression analysis was used to evaluate whether family history of stroke or CHD was associated with presence of CAS, independent of conventional risk factors. RESULTS - : Family history of stroke and CHD was present more often in patients with CAS than in controls, with a resulting odds ratios (95{\%} confidence interval) of 2.02 (1.61-2.53) and 2.01 (1.70-2.37), respectively. The associations remained significant after adjustment for age, sex, body mass index, smoking, diabetes mellitus, hypertension, and dyslipidemia; odds ratios: 1.41 (1.06-1.90) and 1.69 (1.35-2.10), respectively. A greater number of affected relatives with stroke or CHD was associated with higher odds of CAS; adjusted odds ratios: 1.25 (0.91-1.72) and 1.46 (1.14-1.89) versus 2.65 (1.35-5.40) and 2.13 (1.57-2.90) for patients with 1 and ≥2 affected relatives with stroke and CHD, respectively. CONCLUSIONS - : Family history of stroke, and of CHD were each associated with CAS, suggesting that shared genetic and environmental factors contribute to the risk of CAS.",
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T1 - Family history as a risk factor for carotid artery stenosis

AU - Khaleghi, Mahyar

AU - Isseh, Iyad N.

AU - Jouni, Hayan

AU - Sohn, Sunghwan

AU - Bailey, Kent R

AU - Kullo, Iftikhar Jan

PY - 2014

Y1 - 2014

N2 - BACKGROUND AND PURPOSE - : We investigated whether family history of stroke or coronary heart disease (CHD) is associated with presence of carotid artery stenosis (CAS). METHODS - : The study cohort included 864 patients (72±8 years; 68% men) with CAS and 1698 controls (61±11 years; 55% men) referred for noninvasive vascular testing. CAS was defined as ≥70% stenosis in the internal carotid artery on ultrasound or history of carotid revascularization. Controls did not have CAS or history of cerebrovascular disease or CHD. Family history of stroke and CHD was defined as having ≥1 first-degree relative who had stroke or CHD before age 65 years. Logistic regression analysis was used to evaluate whether family history of stroke or CHD was associated with presence of CAS, independent of conventional risk factors. RESULTS - : Family history of stroke and CHD was present more often in patients with CAS than in controls, with a resulting odds ratios (95% confidence interval) of 2.02 (1.61-2.53) and 2.01 (1.70-2.37), respectively. The associations remained significant after adjustment for age, sex, body mass index, smoking, diabetes mellitus, hypertension, and dyslipidemia; odds ratios: 1.41 (1.06-1.90) and 1.69 (1.35-2.10), respectively. A greater number of affected relatives with stroke or CHD was associated with higher odds of CAS; adjusted odds ratios: 1.25 (0.91-1.72) and 1.46 (1.14-1.89) versus 2.65 (1.35-5.40) and 2.13 (1.57-2.90) for patients with 1 and ≥2 affected relatives with stroke and CHD, respectively. CONCLUSIONS - : Family history of stroke, and of CHD were each associated with CAS, suggesting that shared genetic and environmental factors contribute to the risk of CAS.

AB - BACKGROUND AND PURPOSE - : We investigated whether family history of stroke or coronary heart disease (CHD) is associated with presence of carotid artery stenosis (CAS). METHODS - : The study cohort included 864 patients (72±8 years; 68% men) with CAS and 1698 controls (61±11 years; 55% men) referred for noninvasive vascular testing. CAS was defined as ≥70% stenosis in the internal carotid artery on ultrasound or history of carotid revascularization. Controls did not have CAS or history of cerebrovascular disease or CHD. Family history of stroke and CHD was defined as having ≥1 first-degree relative who had stroke or CHD before age 65 years. Logistic regression analysis was used to evaluate whether family history of stroke or CHD was associated with presence of CAS, independent of conventional risk factors. RESULTS - : Family history of stroke and CHD was present more often in patients with CAS than in controls, with a resulting odds ratios (95% confidence interval) of 2.02 (1.61-2.53) and 2.01 (1.70-2.37), respectively. The associations remained significant after adjustment for age, sex, body mass index, smoking, diabetes mellitus, hypertension, and dyslipidemia; odds ratios: 1.41 (1.06-1.90) and 1.69 (1.35-2.10), respectively. A greater number of affected relatives with stroke or CHD was associated with higher odds of CAS; adjusted odds ratios: 1.25 (0.91-1.72) and 1.46 (1.14-1.89) versus 2.65 (1.35-5.40) and 2.13 (1.57-2.90) for patients with 1 and ≥2 affected relatives with stroke and CHD, respectively. CONCLUSIONS - : Family history of stroke, and of CHD were each associated with CAS, suggesting that shared genetic and environmental factors contribute to the risk of CAS.

KW - atherosclerosis

KW - carotid stenosis

KW - coronary heart disease

KW - risk factors

KW - stroke

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