Familial predisposition to lung cancer

Thomas A. Sellers; Gloria M. Petersen; Ping Yang

Familial predisposition to lung cancer

Thomas A. Sellers, Gloria M. Petersen, Ping Yang

Quantitative Health Sciences

Research output: Chapter in Book/Report/Conference proceeding › Chapter

1 Scopus citations

Abstract

Even in the case of a lung malignancy, such as mesothelioma, which is strongly related to asbestos exposure, familial clustering has been reported8,9 and asbestos exposure among some family members could not be proven. While dramatic case reports such as these may offer a striking clinical impression, they do not constitute sufficient evidence for the role of a genetic effect. In particular, rare familial clusters of a disease with such strong environmental influences may simply represent a chance occurrence.

Original language	English (US)
Title of host publication	Genetic Predisposition to Cancer, Second Edition
Publisher	CRC Press
Pages	360-367
Number of pages	8
ISBN (Electronic)	9781444114287
ISBN (Print)	9780340762547
State	Published - Jan 1 2003

ASJC Scopus subject areas

General Medicine
General Biochemistry, Genetics and Molecular Biology

Cite this

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title = "Familial predisposition to lung cancer",

abstract = "Even in the case of a lung malignancy, such as mesothelioma, which is strongly related to asbestos exposure, familial clustering has been reported8,9 and asbestos exposure among some family members could not be proven. While dramatic case reports such as these may offer a striking clinical impression, they do not constitute sufficient evidence for the role of a genetic effect. In particular, rare familial clusters of a disease with such strong environmental influences may simply represent a chance occurrence.",

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N2 - Even in the case of a lung malignancy, such as mesothelioma, which is strongly related to asbestos exposure, familial clustering has been reported8,9 and asbestos exposure among some family members could not be proven. While dramatic case reports such as these may offer a striking clinical impression, they do not constitute sufficient evidence for the role of a genetic effect. In particular, rare familial clusters of a disease with such strong environmental influences may simply represent a chance occurrence.

AB - Even in the case of a lung malignancy, such as mesothelioma, which is strongly related to asbestos exposure, familial clustering has been reported8,9 and asbestos exposure among some family members could not be proven. While dramatic case reports such as these may offer a striking clinical impression, they do not constitute sufficient evidence for the role of a genetic effect. In particular, rare familial clusters of a disease with such strong environmental influences may simply represent a chance occurrence.

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Familial predisposition to lung cancer

Abstract

ASJC Scopus subject areas

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