Familial pancreatic cancer risk

a population-based study in Utah

Divyanshoo R. Kohli, Ken Robert Smith, Jathine Wong, Zhe Yu, Kenneth Boucher, Douglas Orrick Faigel, Rahul Pannala, Randall W. Burt, Karen Curtin, Niloy Jewel Samadder

Research output: Contribution to journalArticle

Abstract

Introduction: Pancreas adenocarcinoma (PC) has an undefined hereditary component. We quantified the familial risk of PC among relatives of patients diagnosed with PC and stratified it based on anatomic location of PC and age and sex of the proband. Methods: This is a retrospective, population-based, case–control study of PC diagnosed in Utah between 1980 and 2011. The Utah population database and cancer registry were used to identify index patients with PC. The risk of PC in first-degree relatives (FDRs), second-degree relatives (SDRs), and first cousins (FCs) of probands was compared with randomly selected sex- and age-matched population controls. Results: A total of 4,095 patients and 40,933 controls were identified. The relative risk (RR) of PC was 1.76 (95% CI 1.35–2.29) in FDRs, 1.42 (95% CI 1.18–1.7) in SDRs and 1.08 (95% CI 0.95–1.23) in FCs of probands compared to relatives of PC-free controls. The RR were elevated in FDRs (1.96, 95% CI 1.45–2.65), SDRs (1.54, 95% CI 1.19–1.98) and FCs (1.18, 95% CI 1.0–1.64) of female probands. Among probands diagnosed as < 65 years, RR was 2.12 (95% CI 1.37–3.28) in FDRs, 1.94 (95% CI 1.44–2.62) in SDRs, and 1.28 (95% CI 1.0–1.64) in FCs. Overall, the RR for PC was elevated in FDRs regardless of the anatomic location of PC. Discussion: There is an increased risk of PC in FDR and more distant relatives of patients with PC. Relatives of female patients with PC and patients diagnosed at age < 65 years are at a significantly increased risk of PC.

Original languageEnglish (US)
JournalJournal of Gastroenterology
DOIs
StatePublished - Jan 1 2019

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Pancreatic Neoplasms
Pancreas
Adenocarcinoma
Population
Population Control
Registries

Keywords

  • Familial
  • Hereditary cancer
  • Pancreatic cancer

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Familial pancreatic cancer risk : a population-based study in Utah. / Kohli, Divyanshoo R.; Smith, Ken Robert; Wong, Jathine; Yu, Zhe; Boucher, Kenneth; Faigel, Douglas Orrick; Pannala, Rahul; Burt, Randall W.; Curtin, Karen; Samadder, Niloy Jewel.

In: Journal of Gastroenterology, 01.01.2019.

Research output: Contribution to journalArticle

Kohli, Divyanshoo R. ; Smith, Ken Robert ; Wong, Jathine ; Yu, Zhe ; Boucher, Kenneth ; Faigel, Douglas Orrick ; Pannala, Rahul ; Burt, Randall W. ; Curtin, Karen ; Samadder, Niloy Jewel. / Familial pancreatic cancer risk : a population-based study in Utah. In: Journal of Gastroenterology. 2019.
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abstract = "Introduction: Pancreas adenocarcinoma (PC) has an undefined hereditary component. We quantified the familial risk of PC among relatives of patients diagnosed with PC and stratified it based on anatomic location of PC and age and sex of the proband. Methods: This is a retrospective, population-based, case–control study of PC diagnosed in Utah between 1980 and 2011. The Utah population database and cancer registry were used to identify index patients with PC. The risk of PC in first-degree relatives (FDRs), second-degree relatives (SDRs), and first cousins (FCs) of probands was compared with randomly selected sex- and age-matched population controls. Results: A total of 4,095 patients and 40,933 controls were identified. The relative risk (RR) of PC was 1.76 (95{\%} CI 1.35–2.29) in FDRs, 1.42 (95{\%} CI 1.18–1.7) in SDRs and 1.08 (95{\%} CI 0.95–1.23) in FCs of probands compared to relatives of PC-free controls. The RR were elevated in FDRs (1.96, 95{\%} CI 1.45–2.65), SDRs (1.54, 95{\%} CI 1.19–1.98) and FCs (1.18, 95{\%} CI 1.0–1.64) of female probands. Among probands diagnosed as < 65 years, RR was 2.12 (95{\%} CI 1.37–3.28) in FDRs, 1.94 (95{\%} CI 1.44–2.62) in SDRs, and 1.28 (95{\%} CI 1.0–1.64) in FCs. Overall, the RR for PC was elevated in FDRs regardless of the anatomic location of PC. Discussion: There is an increased risk of PC in FDR and more distant relatives of patients with PC. Relatives of female patients with PC and patients diagnosed at age < 65 years are at a significantly increased risk of PC.",
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AU - Kohli, Divyanshoo R.

AU - Smith, Ken Robert

AU - Wong, Jathine

AU - Yu, Zhe

AU - Boucher, Kenneth

AU - Faigel, Douglas Orrick

AU - Pannala, Rahul

AU - Burt, Randall W.

AU - Curtin, Karen

AU - Samadder, Niloy Jewel

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N2 - Introduction: Pancreas adenocarcinoma (PC) has an undefined hereditary component. We quantified the familial risk of PC among relatives of patients diagnosed with PC and stratified it based on anatomic location of PC and age and sex of the proband. Methods: This is a retrospective, population-based, case–control study of PC diagnosed in Utah between 1980 and 2011. The Utah population database and cancer registry were used to identify index patients with PC. The risk of PC in first-degree relatives (FDRs), second-degree relatives (SDRs), and first cousins (FCs) of probands was compared with randomly selected sex- and age-matched population controls. Results: A total of 4,095 patients and 40,933 controls were identified. The relative risk (RR) of PC was 1.76 (95% CI 1.35–2.29) in FDRs, 1.42 (95% CI 1.18–1.7) in SDRs and 1.08 (95% CI 0.95–1.23) in FCs of probands compared to relatives of PC-free controls. The RR were elevated in FDRs (1.96, 95% CI 1.45–2.65), SDRs (1.54, 95% CI 1.19–1.98) and FCs (1.18, 95% CI 1.0–1.64) of female probands. Among probands diagnosed as < 65 years, RR was 2.12 (95% CI 1.37–3.28) in FDRs, 1.94 (95% CI 1.44–2.62) in SDRs, and 1.28 (95% CI 1.0–1.64) in FCs. Overall, the RR for PC was elevated in FDRs regardless of the anatomic location of PC. Discussion: There is an increased risk of PC in FDR and more distant relatives of patients with PC. Relatives of female patients with PC and patients diagnosed at age < 65 years are at a significantly increased risk of PC.

AB - Introduction: Pancreas adenocarcinoma (PC) has an undefined hereditary component. We quantified the familial risk of PC among relatives of patients diagnosed with PC and stratified it based on anatomic location of PC and age and sex of the proband. Methods: This is a retrospective, population-based, case–control study of PC diagnosed in Utah between 1980 and 2011. The Utah population database and cancer registry were used to identify index patients with PC. The risk of PC in first-degree relatives (FDRs), second-degree relatives (SDRs), and first cousins (FCs) of probands was compared with randomly selected sex- and age-matched population controls. Results: A total of 4,095 patients and 40,933 controls were identified. The relative risk (RR) of PC was 1.76 (95% CI 1.35–2.29) in FDRs, 1.42 (95% CI 1.18–1.7) in SDRs and 1.08 (95% CI 0.95–1.23) in FCs of probands compared to relatives of PC-free controls. The RR were elevated in FDRs (1.96, 95% CI 1.45–2.65), SDRs (1.54, 95% CI 1.19–1.98) and FCs (1.18, 95% CI 1.0–1.64) of female probands. Among probands diagnosed as < 65 years, RR was 2.12 (95% CI 1.37–3.28) in FDRs, 1.94 (95% CI 1.44–2.62) in SDRs, and 1.28 (95% CI 1.0–1.64) in FCs. Overall, the RR for PC was elevated in FDRs regardless of the anatomic location of PC. Discussion: There is an increased risk of PC in FDR and more distant relatives of patients with PC. Relatives of female patients with PC and patients diagnosed at age < 65 years are at a significantly increased risk of PC.

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