Familial occurrence of primary sclerosing cholangitis and ulcerative colitis

E. M M Quigley, Nicholas F La Russo, J. Ludwig, R. N. MacSween, G. G. Birnie, G. Watkinson

Research output: Contribution to journalArticle

110 Citations (Scopus)

Abstract

Members of three families had primary sclerosing cholangitis and chronic ulcerative colitis. In each family, 2 siblings were affected; in one instance, they were twin brothers. All 6 individuals had primary sclerosing cholangitis and 5 also had ulcerative colitis. These cases represent the first reported instances of the familial occurrence of both primary sclerosing cholangitis and chronic ulcerative colitis; illustrate the typical clinical, laboratory, radiologic, and pathological features of primary sclerosing cholangitis; and support the hypothesis that genetic factors may play a role in the etiology of this obscure disorder.

Original languageEnglish (US)
Pages (from-to)1160-1165
Number of pages6
JournalGastroenterology
Volume85
Issue number5
StatePublished - 1983

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Sclerosing Cholangitis
Ulcerative Colitis
Siblings

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Quigley, E. M. M., La Russo, N. F., Ludwig, J., MacSween, R. N., Birnie, G. G., & Watkinson, G. (1983). Familial occurrence of primary sclerosing cholangitis and ulcerative colitis. Gastroenterology, 85(5), 1160-1165.

Familial occurrence of primary sclerosing cholangitis and ulcerative colitis. / Quigley, E. M M; La Russo, Nicholas F; Ludwig, J.; MacSween, R. N.; Birnie, G. G.; Watkinson, G.

In: Gastroenterology, Vol. 85, No. 5, 1983, p. 1160-1165.

Research output: Contribution to journalArticle

Quigley, EMM, La Russo, NF, Ludwig, J, MacSween, RN, Birnie, GG & Watkinson, G 1983, 'Familial occurrence of primary sclerosing cholangitis and ulcerative colitis', Gastroenterology, vol. 85, no. 5, pp. 1160-1165.
Quigley EMM, La Russo NF, Ludwig J, MacSween RN, Birnie GG, Watkinson G. Familial occurrence of primary sclerosing cholangitis and ulcerative colitis. Gastroenterology. 1983;85(5):1160-1165.
Quigley, E. M M ; La Russo, Nicholas F ; Ludwig, J. ; MacSween, R. N. ; Birnie, G. G. ; Watkinson, G. / Familial occurrence of primary sclerosing cholangitis and ulcerative colitis. In: Gastroenterology. 1983 ; Vol. 85, No. 5. pp. 1160-1165.
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