Familial occurrence of primary sclerosing cholangitis and ulcerative colitis

E. M M Quigley, Nicholas F La Russo, J. Ludwig, R. N. MacSween, G. G. Birnie, G. Watkinson

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110 Scopus citations

Abstract

Members of three families had primary sclerosing cholangitis and chronic ulcerative colitis. In each family, 2 siblings were affected; in one instance, they were twin brothers. All 6 individuals had primary sclerosing cholangitis and 5 also had ulcerative colitis. These cases represent the first reported instances of the familial occurrence of both primary sclerosing cholangitis and chronic ulcerative colitis; illustrate the typical clinical, laboratory, radiologic, and pathological features of primary sclerosing cholangitis; and support the hypothesis that genetic factors may play a role in the etiology of this obscure disorder.

Original languageEnglish (US)
Pages (from-to)1160-1165
Number of pages6
JournalGastroenterology
Volume85
Issue number5
StatePublished - 1983

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ASJC Scopus subject areas

  • Gastroenterology

Cite this

Quigley, E. M. M., La Russo, N. F., Ludwig, J., MacSween, R. N., Birnie, G. G., & Watkinson, G. (1983). Familial occurrence of primary sclerosing cholangitis and ulcerative colitis. Gastroenterology, 85(5), 1160-1165.