TY - JOUR
T1 - Familial monoclonal gammopathy of undetermined significance and multiple myeloma
T2 - Epidemiology, risk factors, and biological characteristics
AU - Greenberg, Alexandra J.
AU - Rajkumar, S. Vincent
AU - Vachon, Celine M.
PY - 2012/6/7
Y1 - 2012/6/7
N2 - Monoclonal gammopathy of undetermined significance (MGUS), a precursor to multiple myeloma (MM), is one of the most common premalignant conditions in the general population. The cause of MGUS is largely unknown. Recent studies show that there is an increased prevalence of MGUS in blood relatives of persons with lymphoproliferative and plasma cell proliferative disorders, suggesting presence of shared underlying genetic influences. In the past few years, additional studies have examined risk factors and biologic characteristics that may contribute to the increased prevalence of MGUS among relatives of probands with MGUS, MM, and other blood malignancies. This article reviews the known epidemiology and risk factors for familial MGUS and myeloma, the risk of lymphoproliferative disorders and other malignancies among blood-relatives of patients with MGUS and MM, and discusses future directions for research.
AB - Monoclonal gammopathy of undetermined significance (MGUS), a precursor to multiple myeloma (MM), is one of the most common premalignant conditions in the general population. The cause of MGUS is largely unknown. Recent studies show that there is an increased prevalence of MGUS in blood relatives of persons with lymphoproliferative and plasma cell proliferative disorders, suggesting presence of shared underlying genetic influences. In the past few years, additional studies have examined risk factors and biologic characteristics that may contribute to the increased prevalence of MGUS among relatives of probands with MGUS, MM, and other blood malignancies. This article reviews the known epidemiology and risk factors for familial MGUS and myeloma, the risk of lymphoproliferative disorders and other malignancies among blood-relatives of patients with MGUS and MM, and discusses future directions for research.
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U2 - 10.1182/blood-2011-11-387324
DO - 10.1182/blood-2011-11-387324
M3 - Review article
C2 - 22354002
AN - SCOPUS:84862526485
SN - 0006-4971
VL - 119
SP - 5359
EP - 5366
JO - Blood
JF - Blood
IS - 23
ER -