Familial insulin resistance and acanthosis nigricans: Presence of a postbinding defect

W. F. Schwenk, R. A. Rizza, L. J. Mandarino, J. E. Gerich, A. B. Hayles, M. W. Haymond

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Abstract

Type A insulin resistance, associated with acanthosis nigricans and menstrual irregularity, has been ascribed to a decreased concentration of insulin receptors. We now report four affected females from one family, a mother and three daughters (including identical twins) who appear to have the type A syndrome. Two of the kindred had no apparent ovarian dysfunction, while the other two had hyperprolactinemia without other findings of polycystic ovary disease, suggesting a genetic disease with variable penetrance. All had normal erythrocyte and monocyte insulin binding. Insulin dose-response studies to assess glucose metabolism and insulin sensitivity were performed in the affected twins. The dose response to insulin was shifted to the right with a decrease in maximal response. These results are consistent with a postbinding defect in insulin action in these patients.

Original languageEnglish (US)
Pages (from-to)33-37
Number of pages5
JournalDiabetes
Volume35
Issue number1
DOIs
StatePublished - Jan 1 1986

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ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Schwenk, W. F., Rizza, R. A., Mandarino, L. J., Gerich, J. E., Hayles, A. B., & Haymond, M. W. (1986). Familial insulin resistance and acanthosis nigricans: Presence of a postbinding defect. Diabetes, 35(1), 33-37. https://doi.org/10.2337/diab.35.1.33