Familial dementia of adult onset with pathological findings of a 'non-specific' nature

R. C. Kim, G. H. Collins, Joseph E Parisi, A. W. Wright, Y. B. Chu

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

A family is described in which 4 of 10 siblings developed a dementing illness that culminated in death within five to six years of onset. The pathological findings in 3 members were strikingly similar, and consisted of widespread nerve cell loss and astrocytosis within the cerebral cortex, status spongiosus within the outer cortical layers and, in 2, nerve cell loss and astrocytosis within the dorsomedial nucleus of the thalamus. It is concluded that the disorder described in this report does not conform precisely to any of the currently recognized categories of familial dementing disease.

Original languageEnglish (US)
Pages (from-to)61-78
Number of pages18
JournalBrain
Volume104
Issue number1
StatePublished - 1981
Externally publishedYes

Fingerprint

Dementia
Gliosis
dementia
Nerve
Neurons
neurons
Mediodorsal Thalamic Nucleus
thalamus
cerebral cortex
Cell
Cortex
Thalamus
Cerebral Cortex
Nucleus
Disorder
death
Nature
Family
Illness
Siblings

ASJC Scopus subject areas

  • Neuroscience(all)
  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Mathematics(all)
  • Statistics and Probability
  • Agricultural and Biological Sciences (miscellaneous)
  • Clinical Neurology

Cite this

Kim, R. C., Collins, G. H., Parisi, J. E., Wright, A. W., & Chu, Y. B. (1981). Familial dementia of adult onset with pathological findings of a 'non-specific' nature. Brain, 104(1), 61-78.

Familial dementia of adult onset with pathological findings of a 'non-specific' nature. / Kim, R. C.; Collins, G. H.; Parisi, Joseph E; Wright, A. W.; Chu, Y. B.

In: Brain, Vol. 104, No. 1, 1981, p. 61-78.

Research output: Contribution to journalArticle

Kim, RC, Collins, GH, Parisi, JE, Wright, AW & Chu, YB 1981, 'Familial dementia of adult onset with pathological findings of a 'non-specific' nature', Brain, vol. 104, no. 1, pp. 61-78.
Kim RC, Collins GH, Parisi JE, Wright AW, Chu YB. Familial dementia of adult onset with pathological findings of a 'non-specific' nature. Brain. 1981;104(1):61-78.
Kim, R. C. ; Collins, G. H. ; Parisi, Joseph E ; Wright, A. W. ; Chu, Y. B. / Familial dementia of adult onset with pathological findings of a 'non-specific' nature. In: Brain. 1981 ; Vol. 104, No. 1. pp. 61-78.
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