Familial Alzheimer's disease-linked presenilin I variants elevate aβ1- 42/1-40 ratio in vitro and in vivo

David R. Borchelt, Gopal Thinakaran, Christopher B. Eckman, Michael K. Lee, Frances Davenport, Tamara Ratovitsky, Cristian Mihail Prada, Grace Kim, Sophia Seekins, Debra Yager, Hilda H. Slunt, Rong Wang, Mary Seeger, Allan I. Levey, Samuel E. Gandy, Neal G. Copeland, Nancy A. Jenkins, Donald L. Price, Steven G. Younkin, Sangram S. Sisodia