Familial Alzheimer's disease and Cortical Lewy bodies: Is there a genetic susceptibility factor?

C. F. Lippa, T. W. Smith, L. Nee, Y. Robitaille, B. Crain, Dennis W Dickson, D. Pulaski-Salo, D. A. Pollen

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

The reason for the occurrence of Lewy body disease (LED) in Alzheimer's disease (AD) patients in unknown. If brains from etiologically different AD groups differ in their tendency to develop cortical Lewy bodies, the concurrence of LED in AD patients may be a manifestation of the AD process in specific AD subsets. To address this issue, we counted cortical Lewy bodies in AD patients with genetic abnormalities on chromosome 14(n = 19), and chromosome 21 (n = 3), sporadic AD (n = 27), Down's syndrome (n = 1) and control (n = 26) patients. Cortical Lewy bodies were occasionally present in AD patients with long-duration disease in most of the above AD subgroups, but were not present in any of our age-matched control cases. We suggest that cortical Lewy body formation may be an intrinsic part of the late pathologic changes of AD regardless of etiology and that it is not specific to any of the AD subtypes studied.

Original languageEnglish (US)
Pages (from-to)191-194
Number of pages4
JournalDementia
Volume6
Issue number4
StatePublished - 1995
Externally publishedYes

Fingerprint

Lewy Bodies
Genetic Predisposition to Disease
Alzheimer Disease
Lewy Body Disease
Chromosomes, Human, Pair 14
Chromosomes, Human, Pair 21
Down Syndrome

Keywords

  • Alzheimer's disease
  • Dementia
  • Lewy body disease

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Neuropsychology and Physiological Psychology

Cite this

Lippa, C. F., Smith, T. W., Nee, L., Robitaille, Y., Crain, B., Dickson, D. W., ... Pollen, D. A. (1995). Familial Alzheimer's disease and Cortical Lewy bodies: Is there a genetic susceptibility factor? Dementia, 6(4), 191-194.

Familial Alzheimer's disease and Cortical Lewy bodies : Is there a genetic susceptibility factor? / Lippa, C. F.; Smith, T. W.; Nee, L.; Robitaille, Y.; Crain, B.; Dickson, Dennis W; Pulaski-Salo, D.; Pollen, D. A.

In: Dementia, Vol. 6, No. 4, 1995, p. 191-194.

Research output: Contribution to journalArticle

Lippa, CF, Smith, TW, Nee, L, Robitaille, Y, Crain, B, Dickson, DW, Pulaski-Salo, D & Pollen, DA 1995, 'Familial Alzheimer's disease and Cortical Lewy bodies: Is there a genetic susceptibility factor?', Dementia, vol. 6, no. 4, pp. 191-194.
Lippa, C. F. ; Smith, T. W. ; Nee, L. ; Robitaille, Y. ; Crain, B. ; Dickson, Dennis W ; Pulaski-Salo, D. ; Pollen, D. A. / Familial Alzheimer's disease and Cortical Lewy bodies : Is there a genetic susceptibility factor?. In: Dementia. 1995 ; Vol. 6, No. 4. pp. 191-194.
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