Familial aggregation of Alzheimer's disease and related disorders: A collaborative re-analysis of case-control studies

C. M. Van Duijn, D. Clayton, V. Chandra, L. Fratiglioni, A. B. Graves, A. Heyman, A. F. Jorm, E. Kokmen, K. Kondo, J. A. Mortimer, Walter A Rocca, S. L. Shalat, H. Soininen, A. Hofman

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Abstract

Case-control studies of Alzheimer's disease were re-analysed to examine the association of Alzheimer's disease with family history in first degree relatives of dementia, Down's syndrome and Parkinson's disease. Overall, the relative risk of Alzheimer's disease for those with at least one first degree relative with dementia was 3.5 (95% confidence interval 2.6-4.6). Stratification according to age of onset of Alzheimer's disease showed that the relative risk decreased with increasing onset age. However, among patients with an onset of disease after 80 years, there were still significantly more subjects with one or more first degree relatives with dementia as compared to controls (relative risk 2.6; 95% confidence interval 1.3-5.2). The relative risk of Alzheimer's disease was significantly lower in patients who had one first degree relative with dementia (relative risk 2.6; 95% confidence interval 2.0-3.5) as compared to those who had two or more affected relatives (relative risk 7.5; 95% confidence interval 3.3-16.7). Furthermore, the re-analysis showed a significant association between Alzheimer's disease and family history of Down's syndrome (relative risk 2.7; 95% confidence interval 1.2-5.7), which was strongest in those patients who had a positive family history of dementia. The relative risk of Alzheimer's disease for those with a positive family history of Parkinson's disease was 2.4 (95% confidence interval 1.0-5.8).

Original languageEnglish (US)
JournalInternational Journal of Epidemiology
Volume20
Issue numberSUPPL. 2
StatePublished - 1991
Externally publishedYes

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Case-Control Studies
Alzheimer Disease
Dementia
Confidence Intervals
Down Syndrome
Age of Onset
Parkinson Disease

ASJC Scopus subject areas

  • Epidemiology

Cite this

Van Duijn, C. M., Clayton, D., Chandra, V., Fratiglioni, L., Graves, A. B., Heyman, A., ... Hofman, A. (1991). Familial aggregation of Alzheimer's disease and related disorders: A collaborative re-analysis of case-control studies. International Journal of Epidemiology, 20(SUPPL. 2).

Familial aggregation of Alzheimer's disease and related disorders : A collaborative re-analysis of case-control studies. / Van Duijn, C. M.; Clayton, D.; Chandra, V.; Fratiglioni, L.; Graves, A. B.; Heyman, A.; Jorm, A. F.; Kokmen, E.; Kondo, K.; Mortimer, J. A.; Rocca, Walter A; Shalat, S. L.; Soininen, H.; Hofman, A.

In: International Journal of Epidemiology, Vol. 20, No. SUPPL. 2, 1991.

Research output: Contribution to journalArticle

Van Duijn, CM, Clayton, D, Chandra, V, Fratiglioni, L, Graves, AB, Heyman, A, Jorm, AF, Kokmen, E, Kondo, K, Mortimer, JA, Rocca, WA, Shalat, SL, Soininen, H & Hofman, A 1991, 'Familial aggregation of Alzheimer's disease and related disorders: A collaborative re-analysis of case-control studies', International Journal of Epidemiology, vol. 20, no. SUPPL. 2.
Van Duijn, C. M. ; Clayton, D. ; Chandra, V. ; Fratiglioni, L. ; Graves, A. B. ; Heyman, A. ; Jorm, A. F. ; Kokmen, E. ; Kondo, K. ; Mortimer, J. A. ; Rocca, Walter A ; Shalat, S. L. ; Soininen, H. ; Hofman, A. / Familial aggregation of Alzheimer's disease and related disorders : A collaborative re-analysis of case-control studies. In: International Journal of Epidemiology. 1991 ; Vol. 20, No. SUPPL. 2.
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