False-negative rates of tumor metastases in the histologic examination of bone marrow

Aminah Jatoi, Gerard E. Dallal, Phuong L. Nguyen

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Recent reports have claimed that bone marrow histology is less sensitive for detecting metastatic tumor than are other methods of marrow examination. These reports, however, did not specify methodologic information, such as the number of slides or tissue sections reviewed. To demonstrate the importance of specifying such information, we reviewed archival, tumor-positive marrow biopsy specimens from our laboratory. By means of a statistical model, we calculated the false-negative rates that would have occurred had random histologic review entailed fewer than 10 slides. Our model demonstrates a progressive increase in the percentage of false-negative diagnoses with the review of fewer slides, e.g., from 1% with review of nine slides to as high as 24% with review of only two slides. We conclude that the number of histologic slides and tissue sections reviewed should be specified when comparing bone marrow histologic examination with other techniques of marrow assessment.

Original languageEnglish (US)
Pages (from-to)29-32
Number of pages4
JournalModern Pathology
Volume12
Issue number1
StatePublished - Jan 1999
Externally publishedYes

Fingerprint

Bone Marrow Examination
Bone Marrow
Neoplasm Metastasis
Neoplasms
Statistical Models
Histology
Biopsy

Keywords

  • Bone marrow biopsy
  • False negative
  • Metastasis
  • Staging

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

False-negative rates of tumor metastases in the histologic examination of bone marrow. / Jatoi, Aminah; Dallal, Gerard E.; Nguyen, Phuong L.

In: Modern Pathology, Vol. 12, No. 1, 01.1999, p. 29-32.

Research output: Contribution to journalArticle

Jatoi, Aminah ; Dallal, Gerard E. ; Nguyen, Phuong L. / False-negative rates of tumor metastases in the histologic examination of bone marrow. In: Modern Pathology. 1999 ; Vol. 12, No. 1. pp. 29-32.
@article{5b71cb29651442a69559986e88fc89ae,
title = "False-negative rates of tumor metastases in the histologic examination of bone marrow",
abstract = "Recent reports have claimed that bone marrow histology is less sensitive for detecting metastatic tumor than are other methods of marrow examination. These reports, however, did not specify methodologic information, such as the number of slides or tissue sections reviewed. To demonstrate the importance of specifying such information, we reviewed archival, tumor-positive marrow biopsy specimens from our laboratory. By means of a statistical model, we calculated the false-negative rates that would have occurred had random histologic review entailed fewer than 10 slides. Our model demonstrates a progressive increase in the percentage of false-negative diagnoses with the review of fewer slides, e.g., from 1{\%} with review of nine slides to as high as 24{\%} with review of only two slides. We conclude that the number of histologic slides and tissue sections reviewed should be specified when comparing bone marrow histologic examination with other techniques of marrow assessment.",
keywords = "Bone marrow biopsy, False negative, Metastasis, Staging",
author = "Aminah Jatoi and Dallal, {Gerard E.} and Nguyen, {Phuong L.}",
year = "1999",
month = "1",
language = "English (US)",
volume = "12",
pages = "29--32",
journal = "Modern Pathology",
issn = "0893-3952",
publisher = "Nature Publishing Group",
number = "1",

}

TY - JOUR

T1 - False-negative rates of tumor metastases in the histologic examination of bone marrow

AU - Jatoi, Aminah

AU - Dallal, Gerard E.

AU - Nguyen, Phuong L.

PY - 1999/1

Y1 - 1999/1

N2 - Recent reports have claimed that bone marrow histology is less sensitive for detecting metastatic tumor than are other methods of marrow examination. These reports, however, did not specify methodologic information, such as the number of slides or tissue sections reviewed. To demonstrate the importance of specifying such information, we reviewed archival, tumor-positive marrow biopsy specimens from our laboratory. By means of a statistical model, we calculated the false-negative rates that would have occurred had random histologic review entailed fewer than 10 slides. Our model demonstrates a progressive increase in the percentage of false-negative diagnoses with the review of fewer slides, e.g., from 1% with review of nine slides to as high as 24% with review of only two slides. We conclude that the number of histologic slides and tissue sections reviewed should be specified when comparing bone marrow histologic examination with other techniques of marrow assessment.

AB - Recent reports have claimed that bone marrow histology is less sensitive for detecting metastatic tumor than are other methods of marrow examination. These reports, however, did not specify methodologic information, such as the number of slides or tissue sections reviewed. To demonstrate the importance of specifying such information, we reviewed archival, tumor-positive marrow biopsy specimens from our laboratory. By means of a statistical model, we calculated the false-negative rates that would have occurred had random histologic review entailed fewer than 10 slides. Our model demonstrates a progressive increase in the percentage of false-negative diagnoses with the review of fewer slides, e.g., from 1% with review of nine slides to as high as 24% with review of only two slides. We conclude that the number of histologic slides and tissue sections reviewed should be specified when comparing bone marrow histologic examination with other techniques of marrow assessment.

KW - Bone marrow biopsy

KW - False negative

KW - Metastasis

KW - Staging

UR - http://www.scopus.com/inward/record.url?scp=0032915327&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032915327&partnerID=8YFLogxK

M3 - Article

VL - 12

SP - 29

EP - 32

JO - Modern Pathology

JF - Modern Pathology

SN - 0893-3952

IS - 1

ER -