Failure of methylprednisolone acetate to prolong the antinauseant effect of intravenous methylprednisolone sodium succinate in patients receiving chemotherapy

D. Osoba, C. Erlichman, A. R. Willan, M. L. Brigden, P. Geggie, J. L. Pater, J. J. Rusthoven, K. S. Wilson

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

The efficacy of intramuscular methylprednisolone acetate in maintaining the antinauseant effect of intravenous methylprednisolone sodium succinate was assessed in a prospectively-randomized, double-blind, crossover-design trial. Of 150 patients entered, 127 were evaluable. There was no statistically significant difference between methylprednisolone acetate and saline placebo, although patient preferences slightly favoured the methylprednisolone acetate for nausea, vomiting, and overall effectiveness.

Original languageEnglish (US)
Pages (from-to)377-379
Number of pages3
JournalClinical and Investigative Medicine
Volume11
Issue number5
StatePublished - Jan 1 1988

ASJC Scopus subject areas

  • Medicine(all)

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    Osoba, D., Erlichman, C., Willan, A. R., Brigden, M. L., Geggie, P., Pater, J. L., Rusthoven, J. J., & Wilson, K. S. (1988). Failure of methylprednisolone acetate to prolong the antinauseant effect of intravenous methylprednisolone sodium succinate in patients receiving chemotherapy. Clinical and Investigative Medicine, 11(5), 377-379.