Failure of carbohydrate to spare leucine oxidation in obese subjects

K Sreekumaran Nair, D. Halliday, G. C. Ford, S. Heels, J. S. Garrow

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Leucine kinetics were studied in six obese subjects (W/H2 = 39 ± 4) and six normal subjects (W/H2 = 21 ± 3) before and after an oral load of 150 g glucose. An intravenous infusion of l-13C leucine was given to the fasting subjects for 450 min: a steady state of plasma leucine enrichment was established 90 min after the start of the infusion, and the glucose load was given 220 min after the start of the infusion. Compared with the lean controls these obese subjects showed a greater area under the curve of blood glucose after the glucose load (P < 0.025) and higher insulin and glucagon levels both before and after the meal (P < 0.05), thus indicating the well-known insulin insensitivity of obese (but not diabetic) subjects with respect to glucose metabolism. After the glucose load the lean subjects showed a significant and sustained decrease in leucine oxidation (from 20.0 ± 2.2 to 13.3 ± 1.5 μmol/kg LBM/h:P < 0.01). This response is similar to that observed when insulin-dependent diabetic subjects are given insulin. However, the obese subjects showed no decrease in leucine oxidation after the glucose meal (20.3 ± 1.9 before, and 21.2 ± 3.6 after). This indicates that obese subjects show insensitivity to the action of insulin with respect to protein metabolism as well as carbohydrate metabolism.

Original languageEnglish (US)
Pages (from-to)537-544
Number of pages8
JournalInternational Journal of Obesity
Volume11
Issue number5
StatePublished - 1987
Externally publishedYes

Fingerprint

Leucine
leucine
Carbohydrates
oxidation
carbohydrates
Glucose
glucose
Insulin
insulin
meals (menu)
Meals
glucagon
Carbohydrate Metabolism
carbohydrate metabolism
protein metabolism
Glucagon
Intravenous Infusions
insulin resistance
blood glucose
Area Under Curve

ASJC Scopus subject areas

  • Food Science
  • Endocrinology
  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Public Health, Environmental and Occupational Health

Cite this

Nair, K. S., Halliday, D., Ford, G. C., Heels, S., & Garrow, J. S. (1987). Failure of carbohydrate to spare leucine oxidation in obese subjects. International Journal of Obesity, 11(5), 537-544.

Failure of carbohydrate to spare leucine oxidation in obese subjects. / Nair, K Sreekumaran; Halliday, D.; Ford, G. C.; Heels, S.; Garrow, J. S.

In: International Journal of Obesity, Vol. 11, No. 5, 1987, p. 537-544.

Research output: Contribution to journalArticle

Nair, KS, Halliday, D, Ford, GC, Heels, S & Garrow, JS 1987, 'Failure of carbohydrate to spare leucine oxidation in obese subjects', International Journal of Obesity, vol. 11, no. 5, pp. 537-544.
Nair, K Sreekumaran ; Halliday, D. ; Ford, G. C. ; Heels, S. ; Garrow, J. S. / Failure of carbohydrate to spare leucine oxidation in obese subjects. In: International Journal of Obesity. 1987 ; Vol. 11, No. 5. pp. 537-544.
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