Failing energetics in failing hearts

Research output: Contribution to journalArticle

86 Citations (Scopus)

Abstract

The perpetual and vigorous nature of heart muscle work requires efficient myocardial energetics. This depends not only on adequate ATP production, but also on efficient delivery of ATP to muscle ATPases and rapid removal of ADP and other by-products of ATP hydrolysis. Indeed, recent evidence indicates that defects in communication between ATP-producing and ATP-consuming cellular sites are a major factor contributing to energetic deficiency in heart failure. In particular, the failing myocardium is characterized by reduced catalytic activity of creatine kinase, adenylate kinase, carbonic anhydrase, and glycolytic enzymes, which collectively facilitate ATP delivery and promote removal of ADP, Pi, and H+ from cellular ATPases. Although energy transfer through adenylate kinase and glycolytic enzymes has been recognized as an adaptive mechanism supporting compromised muscle energetics, in the failing myocardium the total compensatory potential of these systems is diminished. A gradual accumulation of defects at various steps in myocardial energetic signaling, along with compromised compensatory mechanisms, precipitates failure of the whole cardiac energetic system, ultimately contributing to myocardial dysfunction. These advances in our understanding of the molecular bioenergetics in heart failure provide a new perspective toward improving the energetic balance of the failing myocardium.

Original languageEnglish (US)
Pages (from-to)212-217
Number of pages6
JournalCurrent Cardiology Reports
Volume2
Issue number3
DOIs
StatePublished - 2000

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Adenosine Triphosphate
Myocardium
Adenylate Kinase
Heart Failure
Adenosine Diphosphate
Muscles
Proton-Translocating ATPases
Carbonic Anhydrases
Energy Transfer
Enzymes
Creatine Kinase
Energy Metabolism
Adenosine Triphosphatases
Hydrolysis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Failing energetics in failing hearts. / Dzeja, Petras P; Redfield, Margaret May; Burnett, John C Jr.; Terzic, Andre.

In: Current Cardiology Reports, Vol. 2, No. 3, 2000, p. 212-217.

Research output: Contribution to journalArticle

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