Factors Influencing the Uptake of <sup>99m</sup>Tc-Sestamibi in Breast Tissue on Molecular Breast Imaging

Michael K. O'Connor, Carrie B Hruska, Thuy D. Tran, Tiffinee Swanson, Amy Lynn Conners, Katie Jones, Deborah Rhodes

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The purpose of this study was to evaluate the impact of changes to a patient's prandial status, metabolic status (rest vs. exercise), and peripheral blood flow (via caffeine or warming) on the uptake of <sup>99m</sup>Tc-sestamibi in breast tissue. Methods: A total of 154 subjects participated in 1 of 4 study groups that evaluated the effects of 4 types of intervention on the uptake of <sup>99m</sup>Tc-sestamibi in breast tissue (effect of fasting, light exercise, caffeine, and peripheral warming). Molecular breast imaging wasperformed before and after each intervention. Count density was assessed in counts/cm<sup>2</sup>/MBq from the mediolateral oblique view in all studies. Results: Uptake of <sup>99m</sup>Tc-sestamibi in breast tissue increased by approximately 25% from 6.6 counts/cm<sup>2</sup>/MBq in the fed state to 8.3 counts/cm<sup>2</sup>/MBq with fasting. Peripheral warming also resulted in an approximately 20%increase in count density from 9.1 to 10.9 counts/cm<sup>2</sup>/MBq. Conversely, exercise caused a 35% drop in count density relative to the resting state. Uptake did not seem to be influenced by caffeine and did not correlate with a patient's height, weight, or breast thickness. There was only a weak correlation between breast activity and body surface area. Conclusion: The combined effects of fastingand warming resulted in an approximately 50%increased uptake of <sup>99m</sup>Tc-sestamibi in breast tissue relative to that observed in a reference group to whom no preparatory instructions had been given. Optimal patient preparation before administration of <sup>99m</sup>Tc-sestamibi should permit a corresponding reduction in either acquisition time or required dose of <sup>99m</sup>Tc-sestamibi.

Original languageEnglish (US)
Pages (from-to)13-20
Number of pages8
JournalJournal of Nuclear Medicine Technology
Issue number1
StatePublished - 2015



  • <sup>99m</sup>Tc-sestamibi
  • Breast
  • Exercise
  • Fasting

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

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