TY - JOUR
T1 - Factors influencing receptivity to future screening options for pancreatic cancer in those with and without pancreatic cancer family history
AU - Breitkopf, Carmen R.
AU - Sinicrope, Pamela S.
AU - Rabe, Kari G.
AU - Brockman, Tabetha A.
AU - Patten, Christi A.
AU - McWilliams, Robert R.
AU - Ehlers, Shawna
AU - Petersen, Gloria M.
N1 - Funding Information:
This research was supported by the National Cancer Institute grants R01CA97075 and P50 CA102701 (Mayo Clinic Specialized Programs of Research Excellence in Pancreatic Cancer) as well as the Mayo Foundation (Cancer Experience Interest Group). We would like to acknowledge the study participants as well as the individuals who were involved in their recruitment, including Diane Batzel, Susan Bisping, Jodie Cogswell, Traci Hammer, Margaret Landhuis, Karen Olson, Amy Reynolds, Hiedi Treitline, and Cindy Wong. We also thank Jeff Leirness, Que Luu, Martha Matsumoto, and Dennis Robinson for their contributions to the data management.
PY - 2012/6/27
Y1 - 2012/6/27
N2 - Background: Pancreatic cancer (PC) is considered the most lethal cancer and approximately 10% of PC is hereditary. The purpose of the study was to assess attitudes of at-risk family members with two or more relatives affected with pancreas cancer (PC) toward PC risk and future screening options.Methods: At-risk family members and primary care controls were surveyed regarding perceived PC risk, PC worry/concern, attitude toward cancer screening, screening test accuracy, and intentions regarding PC screening via blood testing or more invasive endoscopic ultrasound (EUS).Results: PC family members reported greater perceived risk of PC than controls (54% vs. 6%, respectively, p < 0.0001). PC family members also reported higher levels of PC worry/concern than controls (p < 0.0001), although 19% of PC family members indicated they were " not at all concerned" about getting PC. PC family members indicated greater acceptance of a false-negative result on a PC screening test relative to controls (12% vs. 8%, p = 0.02). Both groups reported high (>89%) receptivity to the potential PC screening options presented, though receptivity was greater among PC family members as compared to controls (p < 0.0001) for EUS. In multivariable analyses, degree of PC concern (p < 0.0001) was associated with intention to screen for PC by blood test and EUS, while perceived PC risk was associated with likelihood of undergoing EUS only (p < 0.0001).Conclusions: Receptivity to screening options for PC appears high. Clinicians should address behavioral and genetic risk factors for PC and foster appropriate concern regarding PC risk among at-risk individuals.
AB - Background: Pancreatic cancer (PC) is considered the most lethal cancer and approximately 10% of PC is hereditary. The purpose of the study was to assess attitudes of at-risk family members with two or more relatives affected with pancreas cancer (PC) toward PC risk and future screening options.Methods: At-risk family members and primary care controls were surveyed regarding perceived PC risk, PC worry/concern, attitude toward cancer screening, screening test accuracy, and intentions regarding PC screening via blood testing or more invasive endoscopic ultrasound (EUS).Results: PC family members reported greater perceived risk of PC than controls (54% vs. 6%, respectively, p < 0.0001). PC family members also reported higher levels of PC worry/concern than controls (p < 0.0001), although 19% of PC family members indicated they were " not at all concerned" about getting PC. PC family members indicated greater acceptance of a false-negative result on a PC screening test relative to controls (12% vs. 8%, p = 0.02). Both groups reported high (>89%) receptivity to the potential PC screening options presented, though receptivity was greater among PC family members as compared to controls (p < 0.0001) for EUS. In multivariable analyses, degree of PC concern (p < 0.0001) was associated with intention to screen for PC by blood test and EUS, while perceived PC risk was associated with likelihood of undergoing EUS only (p < 0.0001).Conclusions: Receptivity to screening options for PC appears high. Clinicians should address behavioral and genetic risk factors for PC and foster appropriate concern regarding PC risk among at-risk individuals.
KW - Health behavior
KW - Pancreatic cancer
KW - Perceived risk
KW - Screening intentions
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U2 - 10.1186/1897-4287-10-8
DO - 10.1186/1897-4287-10-8
M3 - Article
C2 - 22738386
AN - SCOPUS:84864753148
SN - 1731-2302
VL - 10
JO - Hereditary Cancer in Clinical Practice
JF - Hereditary Cancer in Clinical Practice
IS - 1
M1 - 8
ER -