Factors influencing receptivity to future screening options for pancreatic cancer in those with and without pancreatic cancer family history

Carmen R. Breitkopf, Pamela S. Sinicrope, Kari G. Rabe, Tabetha A. Brockman, Christi A. Patten, Robert R. McWilliams, Shawna Ehlers, Gloria M. Petersen

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Background: Pancreatic cancer (PC) is considered the most lethal cancer and approximately 10% of PC is hereditary. The purpose of the study was to assess attitudes of at-risk family members with two or more relatives affected with pancreas cancer (PC) toward PC risk and future screening options.Methods: At-risk family members and primary care controls were surveyed regarding perceived PC risk, PC worry/concern, attitude toward cancer screening, screening test accuracy, and intentions regarding PC screening via blood testing or more invasive endoscopic ultrasound (EUS).Results: PC family members reported greater perceived risk of PC than controls (54% vs. 6%, respectively, p < 0.0001). PC family members also reported higher levels of PC worry/concern than controls (p < 0.0001), although 19% of PC family members indicated they were " not at all concerned" about getting PC. PC family members indicated greater acceptance of a false-negative result on a PC screening test relative to controls (12% vs. 8%, p = 0.02). Both groups reported high (>89%) receptivity to the potential PC screening options presented, though receptivity was greater among PC family members as compared to controls (p < 0.0001) for EUS. In multivariable analyses, degree of PC concern (p < 0.0001) was associated with intention to screen for PC by blood test and EUS, while perceived PC risk was associated with likelihood of undergoing EUS only (p < 0.0001).Conclusions: Receptivity to screening options for PC appears high. Clinicians should address behavioral and genetic risk factors for PC and foster appropriate concern regarding PC risk among at-risk individuals.

Original languageEnglish (US)
Article number8
JournalHereditary Cancer in Clinical Practice
Volume10
Issue number1
DOIs
StatePublished - Jun 27 2012

Keywords

  • Health behavior
  • Pancreatic cancer
  • Perceived risk
  • Screening intentions

ASJC Scopus subject areas

  • Oncology
  • Genetics(clinical)

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