Factors influencing lymph node recovery from the operative specimen after gastrectomy for gastric adenocarcinoma

Scott J. Schoenleber, Thomas Schnelldorfer, Christina M. Wood, Rui Qin, Michael G. Sarr, John H. Donohue

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Background: Regional lymph node metastases are an important predictor of survival for patients with resectable adenocarcinoma of the stomach. Currently, the number of lymph nodes examined is frequently less than requirements for accurate staging. Clinical factors associated with lymph node recovery are understood poorly. Methods: We performed a retrospective chart review of 99 consecutive patients who underwent gastrectomy for gastric adenocarcinoma distal to the gastroesophageal junction to determine clinical variables associated lymph node recovery. Results: Ninety-nine patients underwent gastrectomy for gastric adenocarcinoma at our two hospitals. More than 15 lymph nodes were examined in 64% of specimens. Univariate analysis showed an association between the number of lymph nodes recovered and the number of positive nodes, lymphadenectomy extent, hospital, surgeon, and pathology technician (p∈<∈0.001). Multivariate analysis identified the pathology technician as the most important healthcare-related variable contributing to the variation of lymph node recovery, using fixed- (p∈<∈0.001) and random-effects models. Conclusions: This study suggests that the pathology technician is an important healthcare-related factor influencing lymph node recovery after gastrectomy. In identifying potential areas benefiting from a systems improvements approach, focus on the technical aspects of specimen processing may be of benefit in maximizing the number of lymph nodes recovered.

Original languageEnglish (US)
Pages (from-to)1233-1237
Number of pages5
JournalJournal of Gastrointestinal Surgery
Volume13
Issue number7
DOIs
StatePublished - Jul 2009

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Gastrectomy
Stomach
Adenocarcinoma
Lymph Nodes
Pathology
Delivery of Health Care
Esophagogastric Junction
Lymph Node Excision
Multivariate Analysis
Neoplasm Metastasis
Survival

Keywords

  • Gastric cancer
  • Human factors
  • Lymph nodes
  • Neoplasm staging

ASJC Scopus subject areas

  • Surgery
  • Gastroenterology

Cite this

Factors influencing lymph node recovery from the operative specimen after gastrectomy for gastric adenocarcinoma. / Schoenleber, Scott J.; Schnelldorfer, Thomas; Wood, Christina M.; Qin, Rui; Sarr, Michael G.; Donohue, John H.

In: Journal of Gastrointestinal Surgery, Vol. 13, No. 7, 07.2009, p. 1233-1237.

Research output: Contribution to journalArticle

Schoenleber, Scott J. ; Schnelldorfer, Thomas ; Wood, Christina M. ; Qin, Rui ; Sarr, Michael G. ; Donohue, John H. / Factors influencing lymph node recovery from the operative specimen after gastrectomy for gastric adenocarcinoma. In: Journal of Gastrointestinal Surgery. 2009 ; Vol. 13, No. 7. pp. 1233-1237.
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