Factors in the control of interdigestive and postprandial myoelectric patterns of canine jejunoileum: Role of extrinsic and intrinsic nerves

M. G. Sarr, J. A. Duenes, A. R. Zinsmeister

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Our aim was to determine the roles of extrinsic and intrinsic (enteric) neural continuity to the jejunoileum in control of postprandial and fasting motility patterns. Four groups of dogs were prepared: control, neurally intact; intrinsic transection, distal duodenal transection to disrupt intrinsic myoneural continuity with jejunum; extrinsic transection, transection of all extrinsic nerves to jejunoileum; and intrinsic/extrinsic transection, disruption of both intrinsic myoneural and extrinsic neural continuity to jejunoileum. Duodenal and jejunal electrodes were placed to monitor motility. After 2 weeks, the dogs were studied while fasting, after meals, and during intravenous infusions of cholecystokinin octapeptide at 0.5 μg (kg · h) and pentagastrin at 2 μg (kg · h). During fasting, although the migrating motor complex (MMC) occurred in each region, coordination between duodenum and jejunoileum was disrupted in intrinsic/extrinsic transection dogs, but only partially in intrinsic transection dogs. Small meals (50 g of liver) interrupted the duodenal MMC in all groups and the jejunoileal MMC only in control dogs. A larger (500-g) meal disrupted the MMC in both regions for comparable durations in all groups. Cholecystokinin octapeptide and pentagastrin inhibited the MMC in duodenum and jejunoileum in all groups. Both intrinsic myoneural and extrinsic neural continuity play a role in regional coordination of interdigestive and digestive gut motility. Both hormonal and neural factors (central, enteric) participate in the regulation of onset of postprandial motor patterns.

Original languageEnglish (US)
Pages (from-to)247-257
Number of pages11
JournalJournal of Gastrointestinal Motility
Volume2
Issue number4
StatePublished - 1990

Fingerprint

Migrating Myoelectric Complexes
Canidae
Dogs
Meals
Sincalide
Fasting
Pentagastrin
Duodenum
Jejunum
Intravenous Infusions
Electrodes
Liver

Keywords

  • enteric nerves
  • hormonal control
  • migrating motor complex
  • myoneural continuity
  • neural control
  • postprandial motility

ASJC Scopus subject areas

  • Physiology
  • Gastroenterology

Cite this

Factors in the control of interdigestive and postprandial myoelectric patterns of canine jejunoileum : Role of extrinsic and intrinsic nerves. / Sarr, M. G.; Duenes, J. A.; Zinsmeister, A. R.

In: Journal of Gastrointestinal Motility, Vol. 2, No. 4, 1990, p. 247-257.

Research output: Contribution to journalArticle

@article{9e648f54e1e04be697169a1f18d8c9ff,
title = "Factors in the control of interdigestive and postprandial myoelectric patterns of canine jejunoileum: Role of extrinsic and intrinsic nerves",
abstract = "Our aim was to determine the roles of extrinsic and intrinsic (enteric) neural continuity to the jejunoileum in control of postprandial and fasting motility patterns. Four groups of dogs were prepared: control, neurally intact; intrinsic transection, distal duodenal transection to disrupt intrinsic myoneural continuity with jejunum; extrinsic transection, transection of all extrinsic nerves to jejunoileum; and intrinsic/extrinsic transection, disruption of both intrinsic myoneural and extrinsic neural continuity to jejunoileum. Duodenal and jejunal electrodes were placed to monitor motility. After 2 weeks, the dogs were studied while fasting, after meals, and during intravenous infusions of cholecystokinin octapeptide at 0.5 μg (kg · h) and pentagastrin at 2 μg (kg · h). During fasting, although the migrating motor complex (MMC) occurred in each region, coordination between duodenum and jejunoileum was disrupted in intrinsic/extrinsic transection dogs, but only partially in intrinsic transection dogs. Small meals (50 g of liver) interrupted the duodenal MMC in all groups and the jejunoileal MMC only in control dogs. A larger (500-g) meal disrupted the MMC in both regions for comparable durations in all groups. Cholecystokinin octapeptide and pentagastrin inhibited the MMC in duodenum and jejunoileum in all groups. Both intrinsic myoneural and extrinsic neural continuity play a role in regional coordination of interdigestive and digestive gut motility. Both hormonal and neural factors (central, enteric) participate in the regulation of onset of postprandial motor patterns.",
keywords = "enteric nerves, hormonal control, migrating motor complex, myoneural continuity, neural control, postprandial motility",
author = "Sarr, {M. G.} and Duenes, {J. A.} and Zinsmeister, {A. R.}",
year = "1990",
language = "English (US)",
volume = "2",
pages = "247--257",
journal = "Neurogastroenterology and Motility",
issn = "1350-1925",
publisher = "Wiley-Blackwell",
number = "4",

}

TY - JOUR

T1 - Factors in the control of interdigestive and postprandial myoelectric patterns of canine jejunoileum

T2 - Role of extrinsic and intrinsic nerves

AU - Sarr, M. G.

AU - Duenes, J. A.

AU - Zinsmeister, A. R.

PY - 1990

Y1 - 1990

N2 - Our aim was to determine the roles of extrinsic and intrinsic (enteric) neural continuity to the jejunoileum in control of postprandial and fasting motility patterns. Four groups of dogs were prepared: control, neurally intact; intrinsic transection, distal duodenal transection to disrupt intrinsic myoneural continuity with jejunum; extrinsic transection, transection of all extrinsic nerves to jejunoileum; and intrinsic/extrinsic transection, disruption of both intrinsic myoneural and extrinsic neural continuity to jejunoileum. Duodenal and jejunal electrodes were placed to monitor motility. After 2 weeks, the dogs were studied while fasting, after meals, and during intravenous infusions of cholecystokinin octapeptide at 0.5 μg (kg · h) and pentagastrin at 2 μg (kg · h). During fasting, although the migrating motor complex (MMC) occurred in each region, coordination between duodenum and jejunoileum was disrupted in intrinsic/extrinsic transection dogs, but only partially in intrinsic transection dogs. Small meals (50 g of liver) interrupted the duodenal MMC in all groups and the jejunoileal MMC only in control dogs. A larger (500-g) meal disrupted the MMC in both regions for comparable durations in all groups. Cholecystokinin octapeptide and pentagastrin inhibited the MMC in duodenum and jejunoileum in all groups. Both intrinsic myoneural and extrinsic neural continuity play a role in regional coordination of interdigestive and digestive gut motility. Both hormonal and neural factors (central, enteric) participate in the regulation of onset of postprandial motor patterns.

AB - Our aim was to determine the roles of extrinsic and intrinsic (enteric) neural continuity to the jejunoileum in control of postprandial and fasting motility patterns. Four groups of dogs were prepared: control, neurally intact; intrinsic transection, distal duodenal transection to disrupt intrinsic myoneural continuity with jejunum; extrinsic transection, transection of all extrinsic nerves to jejunoileum; and intrinsic/extrinsic transection, disruption of both intrinsic myoneural and extrinsic neural continuity to jejunoileum. Duodenal and jejunal electrodes were placed to monitor motility. After 2 weeks, the dogs were studied while fasting, after meals, and during intravenous infusions of cholecystokinin octapeptide at 0.5 μg (kg · h) and pentagastrin at 2 μg (kg · h). During fasting, although the migrating motor complex (MMC) occurred in each region, coordination between duodenum and jejunoileum was disrupted in intrinsic/extrinsic transection dogs, but only partially in intrinsic transection dogs. Small meals (50 g of liver) interrupted the duodenal MMC in all groups and the jejunoileal MMC only in control dogs. A larger (500-g) meal disrupted the MMC in both regions for comparable durations in all groups. Cholecystokinin octapeptide and pentagastrin inhibited the MMC in duodenum and jejunoileum in all groups. Both intrinsic myoneural and extrinsic neural continuity play a role in regional coordination of interdigestive and digestive gut motility. Both hormonal and neural factors (central, enteric) participate in the regulation of onset of postprandial motor patterns.

KW - enteric nerves

KW - hormonal control

KW - migrating motor complex

KW - myoneural continuity

KW - neural control

KW - postprandial motility

UR - http://www.scopus.com/inward/record.url?scp=0025226128&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025226128&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:0025226128

VL - 2

SP - 247

EP - 257

JO - Neurogastroenterology and Motility

JF - Neurogastroenterology and Motility

SN - 1350-1925

IS - 4

ER -