Factors correlated with NPPV use in ALS

Carlayne E. Jackson, Steven Lovitt, Neelam Gowda, Frederick Anderson, Robert G. Miller, Walter G. Bradley, Mark B. Bromberg, Benjamin R. Brooks, Neil Cashman, Lora Clawson, Merit Cudkowicz, Dallas A. Forshew, Michael Graves, Terry Heiman-Patterson, Mary Lyon, Hiroshi Mitsumoto, Dan H. Moore, Steven P. Ringel, Jeffrey Rosenfeld, Mark A RossMichael J. Strong, Robert L. Sufit, Valerie Cwik, Linda Boynton De Sepulveda, Yadollah Harati, Raul Mandler, Eric Pioro

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

In spite of emerging evidence of therapeutic benefit from non-invasive positive pressure ventilation (NPPV), only a minority of ALS patients use this therapy. We examined factors which correlate with use of NPPV in ALS patients. Data were analyzed from the ALS CARE Database on the use of NPPV in patients with FVC less than 50% of predicted and probable or definite ALS based on modified El Escorial criteria. Of the 403 eligible patients, 146 (36%) used NPPV. NPPV compliance was strongly correlated with symptoms of dyspnea and orthopnea as well as with the use of other therapies including PEG tubes, augmentative speech devices, and riluzole. Male gender and household income >$80,000 were also associated with higher NPPV use. There was no correlation between age, race, type of insurance, forced vital capacity, duration of symptoms, ALSFRS-R, caregiver burden or quality of life with the use of NPPV. These data suggest that the factors which are most closely associated with NPPV utilization are symptomatic orthopnea and dyspnea. The findings may be useful in designing prospective studies to examine the factors which might explain the underutilization of NPPV and the optimal use of this treatment.

Original languageEnglish (US)
Pages (from-to)80-85
Number of pages6
JournalAmyotrophic Lateral Sclerosis
Volume7
Issue number2
DOIs
StatePublished - Jun 2006

Fingerprint

Positive-Pressure Respiration
Dyspnea
Riluzole
Vital Capacity
Therapeutics
Insurance
Caregivers
Compliance
Quality of Life
Databases
Prospective Studies
Equipment and Supplies

Keywords

  • Amyotrophic lateral sclerosis
  • Bilevel positive airway pressure
  • Database
  • Management
  • Non-invasive positive pressure ventilation

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Jackson, C. E., Lovitt, S., Gowda, N., Anderson, F., Miller, R. G., Bradley, W. G., ... Pioro, E. (2006). Factors correlated with NPPV use in ALS. Amyotrophic Lateral Sclerosis, 7(2), 80-85. https://doi.org/10.1080/14660820500504587

Factors correlated with NPPV use in ALS. / Jackson, Carlayne E.; Lovitt, Steven; Gowda, Neelam; Anderson, Frederick; Miller, Robert G.; Bradley, Walter G.; Bromberg, Mark B.; Brooks, Benjamin R.; Cashman, Neil; Clawson, Lora; Cudkowicz, Merit; Forshew, Dallas A.; Graves, Michael; Heiman-Patterson, Terry; Lyon, Mary; Mitsumoto, Hiroshi; Moore, Dan H.; Ringel, Steven P.; Rosenfeld, Jeffrey; Ross, Mark A; Strong, Michael J.; Sufit, Robert L.; Cwik, Valerie; De Sepulveda, Linda Boynton; Harati, Yadollah; Mandler, Raul; Pioro, Eric.

In: Amyotrophic Lateral Sclerosis, Vol. 7, No. 2, 06.2006, p. 80-85.

Research output: Contribution to journalArticle

Jackson, CE, Lovitt, S, Gowda, N, Anderson, F, Miller, RG, Bradley, WG, Bromberg, MB, Brooks, BR, Cashman, N, Clawson, L, Cudkowicz, M, Forshew, DA, Graves, M, Heiman-Patterson, T, Lyon, M, Mitsumoto, H, Moore, DH, Ringel, SP, Rosenfeld, J, Ross, MA, Strong, MJ, Sufit, RL, Cwik, V, De Sepulveda, LB, Harati, Y, Mandler, R & Pioro, E 2006, 'Factors correlated with NPPV use in ALS', Amyotrophic Lateral Sclerosis, vol. 7, no. 2, pp. 80-85. https://doi.org/10.1080/14660820500504587
Jackson CE, Lovitt S, Gowda N, Anderson F, Miller RG, Bradley WG et al. Factors correlated with NPPV use in ALS. Amyotrophic Lateral Sclerosis. 2006 Jun;7(2):80-85. https://doi.org/10.1080/14660820500504587
Jackson, Carlayne E. ; Lovitt, Steven ; Gowda, Neelam ; Anderson, Frederick ; Miller, Robert G. ; Bradley, Walter G. ; Bromberg, Mark B. ; Brooks, Benjamin R. ; Cashman, Neil ; Clawson, Lora ; Cudkowicz, Merit ; Forshew, Dallas A. ; Graves, Michael ; Heiman-Patterson, Terry ; Lyon, Mary ; Mitsumoto, Hiroshi ; Moore, Dan H. ; Ringel, Steven P. ; Rosenfeld, Jeffrey ; Ross, Mark A ; Strong, Michael J. ; Sufit, Robert L. ; Cwik, Valerie ; De Sepulveda, Linda Boynton ; Harati, Yadollah ; Mandler, Raul ; Pioro, Eric. / Factors correlated with NPPV use in ALS. In: Amyotrophic Lateral Sclerosis. 2006 ; Vol. 7, No. 2. pp. 80-85.
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