Factors contributing to the yield of asymmetric bilateral implantation of intracranial electrodes

Ricky W. Lee, Jayawant Mandrekar, Gregory Alan Worrell, Gregory D Cascino, Nicholas M. Wetjen, Fredric B. Meyer, Elaine C Wirrell, W. Richard Marsh, Elson So

Research output: Contribution to journalArticle

Abstract

Summary Objective To determine the outcome of implanting fewer electrodes over the hemisphere with less supporting presurgical localizing data.

Methods We retrospectively reviewed our epilepsy surgery database at Mayo Clinic, Rochester, Minnesota, between January 1, 1999, and December 31, 2011, to identify patients who had an asymmetric number of electrode contacts implanted in each hemisphere for seizure localization. We scored each presurgical noninvasive data point (0, 0.5, or 1) to predict the likelihood of identifying seizure onset in the hemisphere with fewer intracranial electrode contacts (HFEC). An aggregate score was obtained for each patient.

Results Thirteen (37%) of 35 patients had HFEC-onset seizures on intracranial electroencephalography (iEEG). The following factors predicted HFEC-onset seizures: (1) temporal lobe epilepsy (p = 0.02); (2) interictal scalp electroencephalographic discharges at the HFEC (p = 0.04); and (3) both interictal and ictal scalp EEG discharges at the HFEC (p = 0.01). The median (range) aggregate score was 2 (1-3) for patients with HFEC-onset seizures recorded on iEEG and 1 (0-3) for patients without HFEC-onset seizures (p = 0.001). Using this scoring model, the odds ratio of identifying HFEC-onset seizures on iEEG was 6.4 for each one-point increment in the aggregate score. The area under the receiver operating characteristic curve for this model was 0.84, suggesting excellent ability of the aggregate score to discriminate between patients with and without HFEC-onset seizures on iEEG.

Significance Implanting electrodes on the basis of limited supporting presurgical data may be useful in selected patients, especially those with temporal lobe epilepsy, interictal scalp discharges involving the HFEC, or both interictal and ictal scalp discharges involving the HFEC. In addition, our proposed scoring system may be helpful in selecting patients with complicated epilepsy for implantation of an asymmetric number of intracranial electrodes in the hemispheres.

Original languageEnglish (US)
Pages (from-to)1620-1625
Number of pages6
JournalEpilepsia
Volume55
Issue number10
DOIs
StatePublished - Oct 1 2014

Fingerprint

Electrodes
Seizures
Scalp
Temporal Lobe Epilepsy
Epilepsy
Stroke
Implanted Electrodes
ROC Curve
Electroencephalography
Odds Ratio
Databases
Electrocorticography

Keywords

  • Epilepsy
  • Epilepsy surgery
  • Intracranial electroencephalography

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Medicine(all)

Cite this

Factors contributing to the yield of asymmetric bilateral implantation of intracranial electrodes. / Lee, Ricky W.; Mandrekar, Jayawant; Worrell, Gregory Alan; Cascino, Gregory D; Wetjen, Nicholas M.; Meyer, Fredric B.; Wirrell, Elaine C; Marsh, W. Richard; So, Elson.

In: Epilepsia, Vol. 55, No. 10, 01.10.2014, p. 1620-1625.

Research output: Contribution to journalArticle

Lee, Ricky W. ; Mandrekar, Jayawant ; Worrell, Gregory Alan ; Cascino, Gregory D ; Wetjen, Nicholas M. ; Meyer, Fredric B. ; Wirrell, Elaine C ; Marsh, W. Richard ; So, Elson. / Factors contributing to the yield of asymmetric bilateral implantation of intracranial electrodes. In: Epilepsia. 2014 ; Vol. 55, No. 10. pp. 1620-1625.
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AU - Lee, Ricky W.

AU - Mandrekar, Jayawant

AU - Worrell, Gregory Alan

AU - Cascino, Gregory D

AU - Wetjen, Nicholas M.

AU - Meyer, Fredric B.

AU - Wirrell, Elaine C

AU - Marsh, W. Richard

AU - So, Elson

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AB - Summary Objective To determine the outcome of implanting fewer electrodes over the hemisphere with less supporting presurgical localizing data.Methods We retrospectively reviewed our epilepsy surgery database at Mayo Clinic, Rochester, Minnesota, between January 1, 1999, and December 31, 2011, to identify patients who had an asymmetric number of electrode contacts implanted in each hemisphere for seizure localization. We scored each presurgical noninvasive data point (0, 0.5, or 1) to predict the likelihood of identifying seizure onset in the hemisphere with fewer intracranial electrode contacts (HFEC). An aggregate score was obtained for each patient.Results Thirteen (37%) of 35 patients had HFEC-onset seizures on intracranial electroencephalography (iEEG). The following factors predicted HFEC-onset seizures: (1) temporal lobe epilepsy (p = 0.02); (2) interictal scalp electroencephalographic discharges at the HFEC (p = 0.04); and (3) both interictal and ictal scalp EEG discharges at the HFEC (p = 0.01). The median (range) aggregate score was 2 (1-3) for patients with HFEC-onset seizures recorded on iEEG and 1 (0-3) for patients without HFEC-onset seizures (p = 0.001). Using this scoring model, the odds ratio of identifying HFEC-onset seizures on iEEG was 6.4 for each one-point increment in the aggregate score. The area under the receiver operating characteristic curve for this model was 0.84, suggesting excellent ability of the aggregate score to discriminate between patients with and without HFEC-onset seizures on iEEG.Significance Implanting electrodes on the basis of limited supporting presurgical data may be useful in selected patients, especially those with temporal lobe epilepsy, interictal scalp discharges involving the HFEC, or both interictal and ictal scalp discharges involving the HFEC. In addition, our proposed scoring system may be helpful in selecting patients with complicated epilepsy for implantation of an asymmetric number of intracranial electrodes in the hemispheres.

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