Factors associated with worse outcomes for colorectal neuroendocrine tumors in radical versus local resections

Osayande Osagiede, Elizabeth Habermann, Courtney Day, Emmanuel Gabriel, Amit Merchea, Riccardo Lemini, Iktej S. Jabbal, Dorin T. Colibaseanu

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Background: Colorectal neuroendocrine tumors (NETs) are the most common NETs of the gastrointestinal tract. Due to the rarity, colorectal NETs are understudied and are not clearly understood. Our study sought to identify the factors associated with worse outcomes for colorectal NETs following resection. Methods: We identified patients diagnosed with colorectal NETs [2004-2014] who underwent resection from the National Cancer Data Base. Non-NETs were excluded. Overall survival (OS) was evaluated using the Kaplan Meier method. Cox proportional hazards and logistic regression models were used to assess factors associated with radical versus local resection, OS and LOS. Results: A total of 7,967 colon and 11,929 rectal NETs were analyzed. The majority of colon (93.4%) and rectal (89.1%) NETs underwent radical and local resection respectively. The 5-year OS was 69% and 92% for colon and rectal NETs respectively. Older age (OR 1.45, CI 1.37-1.53) and clinical stage 4 (OR 9.91, CI 4.56-21.52) were associated with higher odds for colonic radical resection. Lowest median income quartile (OR 1.41, CI 1.21-1.64) and African Americans (OR 1.26, CI 1.07-1.49) experienced higher mortality for colon and rectal NETs respectively. Conclusions: Racial minority and low-income patients experience worse outcomes for colorectal NETs following resection.

Original languageEnglish (US)
Pages (from-to)836-846
Number of pages11
JournalJournal of Gastrointestinal Oncology
Volume11
Issue number5
DOIs
StatePublished - Oct 2020

Keywords

  • Colorectal cancer
  • Endoscopic resection
  • National Cancer Data Base
  • Neuroendocrine carcinoma (NEC)
  • Neuroendocrine neoplasms
  • Neuroendocrine tumors (NETs)
  • Outcomes
  • Radical resection

ASJC Scopus subject areas

  • Oncology
  • Gastroenterology

Fingerprint Dive into the research topics of 'Factors associated with worse outcomes for colorectal neuroendocrine tumors in radical versus local resections'. Together they form a unique fingerprint.

Cite this