Factors Associated With Meningioma Detected in a Population-Based Sample

Jane H Cerhan, Alissa Butts, Jeremy A. Syrjanen, Jeremiah A. Aakre, Paul D. Brown, Ronald Carl Petersen, Clifford R Jr. Jack, Rosebud O Roberts

Research output: Contribution to journalArticle

Abstract

Objective: To determine the frequency of incidental meningioma and identify associated factors in a population-based sample of participants who systematically underwent brain imaging. Patients and Methods: We searched the Mayo Clinic Study of Aging, a population-based sample of Olmsted County, Minnesota, residents who underwent longitudinal magnetic resonance imaging of the brain. Using a text search of radiologists’ notes for 2402 individuals (median age, 75.0 years) who underwent imaging between August 10, 2005, and July 31, 2014, we identified 52 patients (2.2%) who had at least one meningioma. We estimated the association of selected risk factors with the presence of meningioma using odds ratios and 95% CIs from logistic regression models adjusted for age and sex. Based on these results, we moved the most significant variables forward to a multivariable model. Results: Controlling for age and sex, significant associations with the presence of meningioma included higher body mass index (odds ratio [OR], 1.06; 95% CI, 1.01-1.12; P=.03), nonsteroidal anti-inflammatory drugs (OR, 2.11; 95% CI, 1.13-3.95; P=.02), aspirin (OR, 1.90; 95% CI, 1.05-3.46; P=.04), and blood pressure–lowering medication (OR, 2.06; 95% CI, 1.06-3.99; P=.03). Lower risk was associated with male sex (OR, 0.51; 95% CI, 0.29-0.90; P=.02), coronary artery disease (OR, 0.46; 95% CI, 0.22-0.97; P=.04), and higher self-reported anxiety (OR, 0.88; 95% CI, 0.78-0.98; P=.02). Simultaneous adjustment for all of these factors except aspirin in a multivariable model did not attenuate these associations (concordance, 0.71). Conclusion: In a population-based sample of 2402 participants, 52 (2.2%) had an incidental meningioma. They were more likely to be female and have higher body mass index. Meningioma was also associated with certain medications (nonsteroidal anti-inflammatory drugs and blood pressure–lowering medications) and inversely with anxiety and coronary artery disease.

Original languageEnglish (US)
Pages (from-to)254-261
Number of pages8
JournalMayo Clinic Proceedings
Volume94
Issue number2
DOIs
StatePublished - Feb 1 2019

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Meningioma
Odds Ratio
Population
Aspirin
Coronary Artery Disease
Body Mass Index
Anti-Inflammatory Agents
Anxiety
Logistic Models
Sex Ratio
Neuroimaging
Pharmaceutical Preparations
Magnetic Resonance Imaging
Brain

ASJC Scopus subject areas

  • Medicine(all)

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Factors Associated With Meningioma Detected in a Population-Based Sample. / Cerhan, Jane H; Butts, Alissa; Syrjanen, Jeremy A.; Aakre, Jeremiah A.; Brown, Paul D.; Petersen, Ronald Carl; Jack, Clifford R Jr.; Roberts, Rosebud O.

In: Mayo Clinic Proceedings, Vol. 94, No. 2, 01.02.2019, p. 254-261.

Research output: Contribution to journalArticle

Cerhan, Jane H ; Butts, Alissa ; Syrjanen, Jeremy A. ; Aakre, Jeremiah A. ; Brown, Paul D. ; Petersen, Ronald Carl ; Jack, Clifford R Jr. ; Roberts, Rosebud O. / Factors Associated With Meningioma Detected in a Population-Based Sample. In: Mayo Clinic Proceedings. 2019 ; Vol. 94, No. 2. pp. 254-261.
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abstract = "Objective: To determine the frequency of incidental meningioma and identify associated factors in a population-based sample of participants who systematically underwent brain imaging. Patients and Methods: We searched the Mayo Clinic Study of Aging, a population-based sample of Olmsted County, Minnesota, residents who underwent longitudinal magnetic resonance imaging of the brain. Using a text search of radiologists’ notes for 2402 individuals (median age, 75.0 years) who underwent imaging between August 10, 2005, and July 31, 2014, we identified 52 patients (2.2{\%}) who had at least one meningioma. We estimated the association of selected risk factors with the presence of meningioma using odds ratios and 95{\%} CIs from logistic regression models adjusted for age and sex. Based on these results, we moved the most significant variables forward to a multivariable model. Results: Controlling for age and sex, significant associations with the presence of meningioma included higher body mass index (odds ratio [OR], 1.06; 95{\%} CI, 1.01-1.12; P=.03), nonsteroidal anti-inflammatory drugs (OR, 2.11; 95{\%} CI, 1.13-3.95; P=.02), aspirin (OR, 1.90; 95{\%} CI, 1.05-3.46; P=.04), and blood pressure–lowering medication (OR, 2.06; 95{\%} CI, 1.06-3.99; P=.03). Lower risk was associated with male sex (OR, 0.51; 95{\%} CI, 0.29-0.90; P=.02), coronary artery disease (OR, 0.46; 95{\%} CI, 0.22-0.97; P=.04), and higher self-reported anxiety (OR, 0.88; 95{\%} CI, 0.78-0.98; P=.02). Simultaneous adjustment for all of these factors except aspirin in a multivariable model did not attenuate these associations (concordance, 0.71). Conclusion: In a population-based sample of 2402 participants, 52 (2.2{\%}) had an incidental meningioma. They were more likely to be female and have higher body mass index. Meningioma was also associated with certain medications (nonsteroidal anti-inflammatory drugs and blood pressure–lowering medications) and inversely with anxiety and coronary artery disease.",
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AU - Cerhan, Jane H

AU - Butts, Alissa

AU - Syrjanen, Jeremy A.

AU - Aakre, Jeremiah A.

AU - Brown, Paul D.

AU - Petersen, Ronald Carl

AU - Jack, Clifford R Jr.

AU - Roberts, Rosebud O

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N2 - Objective: To determine the frequency of incidental meningioma and identify associated factors in a population-based sample of participants who systematically underwent brain imaging. Patients and Methods: We searched the Mayo Clinic Study of Aging, a population-based sample of Olmsted County, Minnesota, residents who underwent longitudinal magnetic resonance imaging of the brain. Using a text search of radiologists’ notes for 2402 individuals (median age, 75.0 years) who underwent imaging between August 10, 2005, and July 31, 2014, we identified 52 patients (2.2%) who had at least one meningioma. We estimated the association of selected risk factors with the presence of meningioma using odds ratios and 95% CIs from logistic regression models adjusted for age and sex. Based on these results, we moved the most significant variables forward to a multivariable model. Results: Controlling for age and sex, significant associations with the presence of meningioma included higher body mass index (odds ratio [OR], 1.06; 95% CI, 1.01-1.12; P=.03), nonsteroidal anti-inflammatory drugs (OR, 2.11; 95% CI, 1.13-3.95; P=.02), aspirin (OR, 1.90; 95% CI, 1.05-3.46; P=.04), and blood pressure–lowering medication (OR, 2.06; 95% CI, 1.06-3.99; P=.03). Lower risk was associated with male sex (OR, 0.51; 95% CI, 0.29-0.90; P=.02), coronary artery disease (OR, 0.46; 95% CI, 0.22-0.97; P=.04), and higher self-reported anxiety (OR, 0.88; 95% CI, 0.78-0.98; P=.02). Simultaneous adjustment for all of these factors except aspirin in a multivariable model did not attenuate these associations (concordance, 0.71). Conclusion: In a population-based sample of 2402 participants, 52 (2.2%) had an incidental meningioma. They were more likely to be female and have higher body mass index. Meningioma was also associated with certain medications (nonsteroidal anti-inflammatory drugs and blood pressure–lowering medications) and inversely with anxiety and coronary artery disease.

AB - Objective: To determine the frequency of incidental meningioma and identify associated factors in a population-based sample of participants who systematically underwent brain imaging. Patients and Methods: We searched the Mayo Clinic Study of Aging, a population-based sample of Olmsted County, Minnesota, residents who underwent longitudinal magnetic resonance imaging of the brain. Using a text search of radiologists’ notes for 2402 individuals (median age, 75.0 years) who underwent imaging between August 10, 2005, and July 31, 2014, we identified 52 patients (2.2%) who had at least one meningioma. We estimated the association of selected risk factors with the presence of meningioma using odds ratios and 95% CIs from logistic regression models adjusted for age and sex. Based on these results, we moved the most significant variables forward to a multivariable model. Results: Controlling for age and sex, significant associations with the presence of meningioma included higher body mass index (odds ratio [OR], 1.06; 95% CI, 1.01-1.12; P=.03), nonsteroidal anti-inflammatory drugs (OR, 2.11; 95% CI, 1.13-3.95; P=.02), aspirin (OR, 1.90; 95% CI, 1.05-3.46; P=.04), and blood pressure–lowering medication (OR, 2.06; 95% CI, 1.06-3.99; P=.03). Lower risk was associated with male sex (OR, 0.51; 95% CI, 0.29-0.90; P=.02), coronary artery disease (OR, 0.46; 95% CI, 0.22-0.97; P=.04), and higher self-reported anxiety (OR, 0.88; 95% CI, 0.78-0.98; P=.02). Simultaneous adjustment for all of these factors except aspirin in a multivariable model did not attenuate these associations (concordance, 0.71). Conclusion: In a population-based sample of 2402 participants, 52 (2.2%) had an incidental meningioma. They were more likely to be female and have higher body mass index. Meningioma was also associated with certain medications (nonsteroidal anti-inflammatory drugs and blood pressure–lowering medications) and inversely with anxiety and coronary artery disease.

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