Factors Associated with Life Expectancy in Patients with Metastatic Spine Disease from Adenocarcinoma of the Lung

C. Rory Goodwin, Mohamed H. Khattab, Eric W. Sankey, Benjamin D. Elder, Thomas A. Kosztowski, Rachel Sarabia Estrada, Ali Bydon, Timothy F. Witham, Jean Paul Wolinsky, Ziya L. Gokaslan, Daniel M. Sciubba

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Study Design Retrospective study. Objective Our objective was to identify preoperative prognostic factors associated with survival in patients with spinal metastasis from lung carcinoma. Methods A retrospective analysis of 26 patients diagnosed with lung carcinoma metastatic to the spinal column was performed to determine factors associated with survival. We used 3 months survival as the clinical cutoff for whether surgical intervention should be performed. We analyzed patients who survived less than 3 months compared with those who survived more than 3 months. Demographic, preoperative, operative, and postoperative factors including functional scores were collected for analysis. Results The median survival for all patients in our study was 3.5 months. We found a statistically significant difference between the group that survived less than 3 months and the group that survived greater than 3 months in terms of extrathoracic metastasis, visceral metastasis, and average postoperative modified Rankin score. Conclusion Determining which patients with lung cancer spinal metastases will benefit from surgical intervention is often dictated by the patient's predicted life expectancy. Factors associated with poorer prognosis include age, functional status, visceral metastases, and extrathoracic metastases. Although the prognosis for patients with lung cancer spinal metastases is poor, some patients may experience long-term benefit from surgical intervention.

Original languageEnglish (US)
Pages (from-to)417-424
Number of pages8
JournalGlobal Spine Journal
Volume5
Issue number5
DOIs
StatePublished - Jan 7 2015
Externally publishedYes

Fingerprint

Life Expectancy
Spine
Neoplasm Metastasis
Survival
Lung Neoplasms
Carcinoma
Lung
Adenocarcinoma of lung
Retrospective Studies
Demography

Keywords

  • adenocarcinoma
  • life expectancy
  • lung cancer
  • metastasis
  • prognostic factors
  • spine
  • surgery
  • tumor

ASJC Scopus subject areas

  • Surgery
  • Orthopedics and Sports Medicine
  • Clinical Neurology

Cite this

Factors Associated with Life Expectancy in Patients with Metastatic Spine Disease from Adenocarcinoma of the Lung. / Goodwin, C. Rory; Khattab, Mohamed H.; Sankey, Eric W.; Elder, Benjamin D.; Kosztowski, Thomas A.; Sarabia Estrada, Rachel; Bydon, Ali; Witham, Timothy F.; Wolinsky, Jean Paul; Gokaslan, Ziya L.; Sciubba, Daniel M.

In: Global Spine Journal, Vol. 5, No. 5, 07.01.2015, p. 417-424.

Research output: Contribution to journalArticle

Goodwin, CR, Khattab, MH, Sankey, EW, Elder, BD, Kosztowski, TA, Sarabia Estrada, R, Bydon, A, Witham, TF, Wolinsky, JP, Gokaslan, ZL & Sciubba, DM 2015, 'Factors Associated with Life Expectancy in Patients with Metastatic Spine Disease from Adenocarcinoma of the Lung', Global Spine Journal, vol. 5, no. 5, pp. 417-424. https://doi.org/10.1055/s-0035-1554778
Goodwin, C. Rory ; Khattab, Mohamed H. ; Sankey, Eric W. ; Elder, Benjamin D. ; Kosztowski, Thomas A. ; Sarabia Estrada, Rachel ; Bydon, Ali ; Witham, Timothy F. ; Wolinsky, Jean Paul ; Gokaslan, Ziya L. ; Sciubba, Daniel M. / Factors Associated with Life Expectancy in Patients with Metastatic Spine Disease from Adenocarcinoma of the Lung. In: Global Spine Journal. 2015 ; Vol. 5, No. 5. pp. 417-424.
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abstract = "Study Design Retrospective study. Objective Our objective was to identify preoperative prognostic factors associated with survival in patients with spinal metastasis from lung carcinoma. Methods A retrospective analysis of 26 patients diagnosed with lung carcinoma metastatic to the spinal column was performed to determine factors associated with survival. We used 3 months survival as the clinical cutoff for whether surgical intervention should be performed. We analyzed patients who survived less than 3 months compared with those who survived more than 3 months. Demographic, preoperative, operative, and postoperative factors including functional scores were collected for analysis. Results The median survival for all patients in our study was 3.5 months. We found a statistically significant difference between the group that survived less than 3 months and the group that survived greater than 3 months in terms of extrathoracic metastasis, visceral metastasis, and average postoperative modified Rankin score. Conclusion Determining which patients with lung cancer spinal metastases will benefit from surgical intervention is often dictated by the patient's predicted life expectancy. Factors associated with poorer prognosis include age, functional status, visceral metastases, and extrathoracic metastases. Although the prognosis for patients with lung cancer spinal metastases is poor, some patients may experience long-term benefit from surgical intervention.",
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