Factor XII deficiency acquired by orthotopic liver transplantation: Case report and review of the literature

N. K. Osborn, Y. Ustundag, C. S. Zent, R. H. Wiesner, C. B. Rosen, K. V. Narayanan Menon

Research output: Contribution to journalReview article

8 Scopus citations

Abstract

Transmission of congenital clotting factor deficiencies after orthotopic liver transplantation is rare. There are published reports of liver donor-to-recipient transmission of protein C deficiency with dysfibrinogenemia, protein S, factor VII and factor XI deficiencies. We report a case of transmission of factor XII deficiency with liver transplantation in a patient with Budd-Chiari syndrome. There was a persistent elevation of the activated partial thromboplastin time (aPTT), but no evidence of bleeding while the patient was maintained on warfarin. The presence of a persistently abnormal aPTT may raise suspicion for the presence of a clotting factor deficiency; however, deficiencies of other clotting factors may not be readily apparent on routine blood tests performed in a donor. Being aware of the possibilities of transmission of these inherited deficiencies of coagulation factors will aid in their early detection and management in the transplant donor and recipient.

Original languageEnglish (US)
Pages (from-to)1743-1745
Number of pages3
JournalAmerican Journal of Transplantation
Volume6
Issue number7
DOIs
StatePublished - Jul 2006

Keywords

  • Budd-Chiari syndrome
  • Clotting factors
  • Coagulation
  • Factor XII deficiency
  • Hypercoagulable

ASJC Scopus subject areas

  • Immunology and Allergy
  • Transplantation
  • Pharmacology (medical)

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