Abstract
Transmission of congenital clotting factor deficiencies after orthotopic liver transplantation is rare. There are published reports of liver donor-to-recipient transmission of protein C deficiency with dysfibrinogenemia, protein S, factor VII and factor XI deficiencies. We report a case of transmission of factor XII deficiency with liver transplantation in a patient with Budd-Chiari syndrome. There was a persistent elevation of the activated partial thromboplastin time (aPTT), but no evidence of bleeding while the patient was maintained on warfarin. The presence of a persistently abnormal aPTT may raise suspicion for the presence of a clotting factor deficiency; however, deficiencies of other clotting factors may not be readily apparent on routine blood tests performed in a donor. Being aware of the possibilities of transmission of these inherited deficiencies of coagulation factors will aid in their early detection and management in the transplant donor and recipient.
Original language | English (US) |
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Pages (from-to) | 1743-1745 |
Number of pages | 3 |
Journal | American Journal of Transplantation |
Volume | 6 |
Issue number | 7 |
DOIs | |
State | Published - Jul 2006 |
Keywords
- Budd-Chiari syndrome
- Clotting factors
- Coagulation
- Factor XII deficiency
- Hypercoagulable
ASJC Scopus subject areas
- Immunology and Allergy
- Transplantation
- Pharmacology (medical)