Factor VIII related antigen in adenomatoid tumors. Implications for histogenesis

D. A. Bell, Thomas J Flotte

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

The current study was undertaken to reevaluate the histogenesis of adenomatoid tumor by an immunoperoxidase method of detecting factor VIII related antigen, a tissue specific marker for vascular endothelium. Three of eight adenomatoid tumors showed diffuse cytoplasmic staining of the cells lining the lumina. When the results were correlated with the light and electron microscopy, it was found that there were two distinct groups of tumors. The vascular adenomatoid tumors stained positively for factor VIII related antigen and did not have tumor cells between tubules. The mesothelial adenomatoid tumors did not stain for factor VIII related antigen, had individual and solid nests of tumor cells between the tubules and had mesothelial characteristics on electron microscopy. These results strongly suggest that adenomatoid tumors can be subdivided into tumors of either mesothelial or vascular endothelial origin, and that these two groups can be distinguished on light microscopy.

Original languageEnglish (US)
Pages (from-to)932-938
Number of pages7
JournalCancer
Volume50
Issue number5
StatePublished - 1982
Externally publishedYes

Fingerprint

Adenomatoid Tumor
von Willebrand Factor
Blood Vessels
Neoplasms
Electron Microscopy
Light
Vascular Endothelium
Microscopy
Coloring Agents
Staining and Labeling

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Factor VIII related antigen in adenomatoid tumors. Implications for histogenesis. / Bell, D. A.; Flotte, Thomas J.

In: Cancer, Vol. 50, No. 5, 1982, p. 932-938.

Research output: Contribution to journalArticle

@article{0a6c103d0ee1474f88d0781d13a9ba34,
title = "Factor VIII related antigen in adenomatoid tumors. Implications for histogenesis",
abstract = "The current study was undertaken to reevaluate the histogenesis of adenomatoid tumor by an immunoperoxidase method of detecting factor VIII related antigen, a tissue specific marker for vascular endothelium. Three of eight adenomatoid tumors showed diffuse cytoplasmic staining of the cells lining the lumina. When the results were correlated with the light and electron microscopy, it was found that there were two distinct groups of tumors. The vascular adenomatoid tumors stained positively for factor VIII related antigen and did not have tumor cells between tubules. The mesothelial adenomatoid tumors did not stain for factor VIII related antigen, had individual and solid nests of tumor cells between the tubules and had mesothelial characteristics on electron microscopy. These results strongly suggest that adenomatoid tumors can be subdivided into tumors of either mesothelial or vascular endothelial origin, and that these two groups can be distinguished on light microscopy.",
author = "Bell, {D. A.} and Flotte, {Thomas J}",
year = "1982",
language = "English (US)",
volume = "50",
pages = "932--938",
journal = "Cancer",
issn = "0008-543X",
publisher = "John Wiley and Sons Inc.",
number = "5",

}

TY - JOUR

T1 - Factor VIII related antigen in adenomatoid tumors. Implications for histogenesis

AU - Bell, D. A.

AU - Flotte, Thomas J

PY - 1982

Y1 - 1982

N2 - The current study was undertaken to reevaluate the histogenesis of adenomatoid tumor by an immunoperoxidase method of detecting factor VIII related antigen, a tissue specific marker for vascular endothelium. Three of eight adenomatoid tumors showed diffuse cytoplasmic staining of the cells lining the lumina. When the results were correlated with the light and electron microscopy, it was found that there were two distinct groups of tumors. The vascular adenomatoid tumors stained positively for factor VIII related antigen and did not have tumor cells between tubules. The mesothelial adenomatoid tumors did not stain for factor VIII related antigen, had individual and solid nests of tumor cells between the tubules and had mesothelial characteristics on electron microscopy. These results strongly suggest that adenomatoid tumors can be subdivided into tumors of either mesothelial or vascular endothelial origin, and that these two groups can be distinguished on light microscopy.

AB - The current study was undertaken to reevaluate the histogenesis of adenomatoid tumor by an immunoperoxidase method of detecting factor VIII related antigen, a tissue specific marker for vascular endothelium. Three of eight adenomatoid tumors showed diffuse cytoplasmic staining of the cells lining the lumina. When the results were correlated with the light and electron microscopy, it was found that there were two distinct groups of tumors. The vascular adenomatoid tumors stained positively for factor VIII related antigen and did not have tumor cells between tubules. The mesothelial adenomatoid tumors did not stain for factor VIII related antigen, had individual and solid nests of tumor cells between the tubules and had mesothelial characteristics on electron microscopy. These results strongly suggest that adenomatoid tumors can be subdivided into tumors of either mesothelial or vascular endothelial origin, and that these two groups can be distinguished on light microscopy.

UR - http://www.scopus.com/inward/record.url?scp=0019974381&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019974381&partnerID=8YFLogxK

M3 - Article

VL - 50

SP - 932

EP - 938

JO - Cancer

JF - Cancer

SN - 0008-543X

IS - 5

ER -