TY - JOUR
T1 - Facilitated endogenous repair
T2 - Making tissue engineering simple, practical, and economical
AU - Evans, Chris H.
AU - Palmer, Glyn D.
AU - Pascher, Arnulf
AU - Porter, Ryan
AU - Kwong, Francois N.
AU - Gouze, Elvire
AU - Gouze, Jean Noel
AU - Liu, Fangjun
AU - Steinert, Andre
AU - Betz, Oliver
AU - Betz, Volker
AU - Vrahas, Mark
AU - Ghivizzani, Steven C.
PY - 2007/8
Y1 - 2007/8
N2 - Facilitated endogenous repair is a novel approach to tissue engineering that avoids the ex vivo culture of autologous cells and the need for manufactured scaffolds, while minimizing the number and invasiveness of associated clinical procedures. The strategy relies on harnessing the intrinsic regenerative potential of endogenous tissues using molecular stimuli, such as gene transfer, to initiate reparative processes in situ. In the simplest example, direct percutaneous injection of an osteogenic vector is used to stimulate bone healing. If necessary, additional progenitor cells and space-filling scaffolds can be provided by autologous bone marrow, muscle, fat, and perhaps other tissues. These can be harvested, processed, and reimplanted by simple, expedited, intraoperative procedures. Examples of repair of experimental osseous and osteochondral lesions in laboratory animals are described. If successful, these strategies will provide methods for tissue regeneration that are not only effective but also inexpensive, safe, and clinically expeditious. Although orthopaedic examples are given here, the technology should be more generally applicable.
AB - Facilitated endogenous repair is a novel approach to tissue engineering that avoids the ex vivo culture of autologous cells and the need for manufactured scaffolds, while minimizing the number and invasiveness of associated clinical procedures. The strategy relies on harnessing the intrinsic regenerative potential of endogenous tissues using molecular stimuli, such as gene transfer, to initiate reparative processes in situ. In the simplest example, direct percutaneous injection of an osteogenic vector is used to stimulate bone healing. If necessary, additional progenitor cells and space-filling scaffolds can be provided by autologous bone marrow, muscle, fat, and perhaps other tissues. These can be harvested, processed, and reimplanted by simple, expedited, intraoperative procedures. Examples of repair of experimental osseous and osteochondral lesions in laboratory animals are described. If successful, these strategies will provide methods for tissue regeneration that are not only effective but also inexpensive, safe, and clinically expeditious. Although orthopaedic examples are given here, the technology should be more generally applicable.
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U2 - 10.1089/ten.2006.0302
DO - 10.1089/ten.2006.0302
M3 - Review article
C2 - 17518747
AN - SCOPUS:34548085955
SN - 1076-3279
VL - 13
SP - 1987
EP - 1993
JO - Tissue Engineering
JF - Tissue Engineering
IS - 8
ER -