Facile syntheses of functionalized toll-like receptor 7 agonists

Babatope Akinbobuyi; Matthew R. Byrd; Charles A. Chang; Mysa Nguyen; Zacharie J. Seifert; Anne Laure Flamar; Gerard Zurawski; Katherine C. Upchurch; Sangkon Oh; Stephen H. Dempsey; Thomas J. Enke; John Le; Hunter J. Winstead; José R. Boquín; Robert R. Kane

doi:10.1016/j.tetlet.2014.11.126

Facile syntheses of functionalized toll-like receptor 7 agonists

Babatope Akinbobuyi, Matthew R. Byrd, Charles A. Chang, Mysa Nguyen, Zacharie J. Seifert, Anne Laure Flamar, Gerard Zurawski, Katherine C. Upchurch, Sangkon Oh, Stephen H. Dempsey, Thomas J. Enke, John Le, Hunter J. Winstead, José R. Boquín, Robert R. Kane

Allergy, Asthma and Clinical Immunology

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Protein conjugates of toll-like receptor 7 agonists have been shown to elicit powerful immune responses. In order to facilitate our studies in this area our group has developed efficient syntheses for a number of functionalized derivatives that retain immune stimulatory activity.

Original language	English (US)
Pages (from-to)	458-460
Number of pages	3
Journal	Tetrahedron Letters
Volume	56
Issue number	2
DOIs	https://doi.org/10.1016/j.tetlet.2014.11.126
State	Published - Jan 8 2015

Keywords

Adenine derivatives
Immune activation
Toll-like receptor
Vaccines

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/j.tetlet.2014.11.126

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title = "Facile syntheses of functionalized toll-like receptor 7 agonists",

abstract = "Protein conjugates of toll-like receptor 7 agonists have been shown to elicit powerful immune responses. In order to facilitate our studies in this area our group has developed efficient syntheses for a number of functionalized derivatives that retain immune stimulatory activity.",

keywords = "Adenine derivatives, Immune activation, Toll-like receptor, Vaccines",

author = "Babatope Akinbobuyi and Byrd, {Matthew R.} and Chang, {Charles A.} and Mysa Nguyen and Seifert, {Zacharie J.} and Flamar, {Anne Laure} and Gerard Zurawski and Upchurch, {Katherine C.} and Sangkon Oh and Dempsey, {Stephen H.} and Enke, {Thomas J.} and John Le and Winstead, {Hunter J.} and Boqu{\'i}n, {Jos{\'e} R.} and Kane, {Robert R.}",

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doi = "10.1016/j.tetlet.2014.11.126",

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T1 - Facile syntheses of functionalized toll-like receptor 7 agonists

AU - Akinbobuyi, Babatope

AU - Byrd, Matthew R.

AU - Chang, Charles A.

AU - Nguyen, Mysa

AU - Seifert, Zacharie J.

AU - Flamar, Anne Laure

AU - Zurawski, Gerard

AU - Upchurch, Katherine C.

AU - Oh, Sangkon

AU - Dempsey, Stephen H.

AU - Enke, Thomas J.

AU - Le, John

AU - Winstead, Hunter J.

AU - Boquín, José R.

AU - Kane, Robert R.

PY - 2015/1/8

Y1 - 2015/1/8

N2 - Protein conjugates of toll-like receptor 7 agonists have been shown to elicit powerful immune responses. In order to facilitate our studies in this area our group has developed efficient syntheses for a number of functionalized derivatives that retain immune stimulatory activity.

AB - Protein conjugates of toll-like receptor 7 agonists have been shown to elicit powerful immune responses. In order to facilitate our studies in this area our group has developed efficient syntheses for a number of functionalized derivatives that retain immune stimulatory activity.

KW - Adenine derivatives

KW - Immune activation

KW - Toll-like receptor

KW - Vaccines

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DO - 10.1016/j.tetlet.2014.11.126

M3 - Article

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SP - 458

EP - 460

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 2

ER -

Facile syntheses of functionalized toll-like receptor 7 agonists

Abstract

Keywords

ASJC Scopus subject areas

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