Facile syntheses of functionalized toll-like receptor 7 agonists

Babatope Akinbobuyi, Matthew R. Byrd, Charles A. Chang, Mysa Nguyen, Zacharie J. Seifert, Anne Laure Flamar, Gerard Zurawski, Katherine C. Upchurch, SangKon Oh, Stephen H. Dempsey, Thomas J. Enke, John Le, Hunter J. Winstead, José R. Boquín, Robert R. Kane

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Protein conjugates of toll-like receptor 7 agonists have been shown to elicit powerful immune responses. In order to facilitate our studies in this area our group has developed efficient syntheses for a number of functionalized derivatives that retain immune stimulatory activity.

Original languageEnglish (US)
Pages (from-to)458-460
Number of pages3
JournalTetrahedron Letters
Volume56
Issue number2
DOIs
StatePublished - Jan 8 2015
Externally publishedYes

Fingerprint

Toll-Like Receptor 7
Derivatives
Proteins

Keywords

  • Adenine derivatives
  • Immune activation
  • Toll-like receptor
  • Vaccines

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Cite this

Akinbobuyi, B., Byrd, M. R., Chang, C. A., Nguyen, M., Seifert, Z. J., Flamar, A. L., ... Kane, R. R. (2015). Facile syntheses of functionalized toll-like receptor 7 agonists. Tetrahedron Letters, 56(2), 458-460. https://doi.org/10.1016/j.tetlet.2014.11.126

Facile syntheses of functionalized toll-like receptor 7 agonists. / Akinbobuyi, Babatope; Byrd, Matthew R.; Chang, Charles A.; Nguyen, Mysa; Seifert, Zacharie J.; Flamar, Anne Laure; Zurawski, Gerard; Upchurch, Katherine C.; Oh, SangKon; Dempsey, Stephen H.; Enke, Thomas J.; Le, John; Winstead, Hunter J.; Boquín, José R.; Kane, Robert R.

In: Tetrahedron Letters, Vol. 56, No. 2, 08.01.2015, p. 458-460.

Research output: Contribution to journalArticle

Akinbobuyi, B, Byrd, MR, Chang, CA, Nguyen, M, Seifert, ZJ, Flamar, AL, Zurawski, G, Upchurch, KC, Oh, S, Dempsey, SH, Enke, TJ, Le, J, Winstead, HJ, Boquín, JR & Kane, RR 2015, 'Facile syntheses of functionalized toll-like receptor 7 agonists', Tetrahedron Letters, vol. 56, no. 2, pp. 458-460. https://doi.org/10.1016/j.tetlet.2014.11.126
Akinbobuyi B, Byrd MR, Chang CA, Nguyen M, Seifert ZJ, Flamar AL et al. Facile syntheses of functionalized toll-like receptor 7 agonists. Tetrahedron Letters. 2015 Jan 8;56(2):458-460. https://doi.org/10.1016/j.tetlet.2014.11.126
Akinbobuyi, Babatope ; Byrd, Matthew R. ; Chang, Charles A. ; Nguyen, Mysa ; Seifert, Zacharie J. ; Flamar, Anne Laure ; Zurawski, Gerard ; Upchurch, Katherine C. ; Oh, SangKon ; Dempsey, Stephen H. ; Enke, Thomas J. ; Le, John ; Winstead, Hunter J. ; Boquín, José R. ; Kane, Robert R. / Facile syntheses of functionalized toll-like receptor 7 agonists. In: Tetrahedron Letters. 2015 ; Vol. 56, No. 2. pp. 458-460.
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