Facile syntheses of functionalized toll-like receptor 7 agonists

Babatope Akinbobuyi; Matthew R. Byrd; Charles A. Chang; Mysa Nguyen; Zacharie J. Seifert; Anne Laure Flamar; Gerard Zurawski; Katherine C. Upchurch; SangKon Oh; Stephen H. Dempsey; Thomas J. Enke; John Le; Hunter J. Winstead; José R. Boquín; Robert R. Kane

doi:10.1016/j.tetlet.2014.11.126

Facile syntheses of functionalized toll-like receptor 7 agonists

Babatope Akinbobuyi, Matthew R. Byrd, Charles A. Chang, Mysa Nguyen, Zacharie J. Seifert, Anne Laure Flamar, Gerard Zurawski, Katherine C. Upchurch, SangKon Oh, Stephen H. Dempsey, Thomas J. Enke, John Le, Hunter J. Winstead, José R. Boquín, Robert R. Kane

Research output: Contribution to journal › Article

3 Scopus citations

Abstract

Protein conjugates of toll-like receptor 7 agonists have been shown to elicit powerful immune responses. In order to facilitate our studies in this area our group has developed efficient syntheses for a number of functionalized derivatives that retain immune stimulatory activity.

Original language	English (US)
Pages (from-to)	458-460
Number of pages	3
Journal	Tetrahedron Letters
Volume	56
Issue number	2
DOIs	https://doi.org/10.1016/j.tetlet.2014.11.126
State	Published - Jan 8 2015
Externally published	Yes

Keywords

Adenine derivatives
Immune activation
Toll-like receptor
Vaccines

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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Akinbobuyi, B., Byrd, M. R., Chang, C. A., Nguyen, M., Seifert, Z. J., Flamar, A. L., Zurawski, G., Upchurch, K. C., Oh, S., Dempsey, S. H., Enke, T. J., Le, J., Winstead, H. J., Boquín, J. R., & Kane, R. R. (2015). Facile syntheses of functionalized toll-like receptor 7 agonists. Tetrahedron Letters, 56(2), 458-460. https://doi.org/10.1016/j.tetlet.2014.11.126

Facile syntheses of functionalized toll-like receptor 7 agonists. / Akinbobuyi, Babatope; Byrd, Matthew R.; Chang, Charles A.; Nguyen, Mysa; Seifert, Zacharie J.; Flamar, Anne Laure; Zurawski, Gerard; Upchurch, Katherine C.; Oh, SangKon; Dempsey, Stephen H.; Enke, Thomas J.; Le, John; Winstead, Hunter J.; Boquín, José R.; Kane, Robert R.

In: Tetrahedron Letters, Vol. 56, No. 2, 08.01.2015, p. 458-460.

Research output: Contribution to journal › Article

Akinbobuyi, Babatope ; Byrd, Matthew R. ; Chang, Charles A. ; Nguyen, Mysa ; Seifert, Zacharie J. ; Flamar, Anne Laure ; Zurawski, Gerard ; Upchurch, Katherine C. ; Oh, SangKon ; Dempsey, Stephen H. ; Enke, Thomas J. ; Le, John ; Winstead, Hunter J. ; Boquín, José R. ; Kane, Robert R. / Facile syntheses of functionalized toll-like receptor 7 agonists. In: Tetrahedron Letters. 2015 ; Vol. 56, No. 2. pp. 458-460.

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AU - Zurawski, Gerard

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