Fabrication of small caliber stent-grafts using electrospinning and balloon expandable bare metal stents

Susheil Uthamaraj, Brandon J. Tefft, Soumen Jana, Ota Hlinomaz, Manju Kalra, Amir Lerman, Dan Dragomir-Daescu, Gurpreet S. Sandhu

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Stent-grafts are widely used for the treatment of various conditions such as aortic lesions, aneurysms, emboli due to coronary intervention procedures and perforations in vasculature. Such stent-grafts are manufactured by covering a stent with a polymer membrane. An ideal stentgraft should have a biocompatible stent covered by a porous, thromboresistant, and biocompatible polymer membrane which mimics the extracellular matrix thereby promoting injury site healing. The goal of this protocol is to manufacture a small caliber stent-graft by encapsulating a balloon expandable stent within two layers of electrospun polyurethane nanofibers. Electrospinning of polyurethane has been shown to assist in healing by mimicking native extracellular matrix, thereby promoting endothelialization. Electrospinning polyurethane nanofibers on a slowly rotating mandrel enabled us to precisely control the thickness of the nanofibrous membrane, which is essential to achieve a small caliber balloon expandable stent-graft. Mechanical validation by crimping and expansion of the stent-graft has shown that the nanofibrous polyurethane membrane is sufficiently flexible to crimp and expand while staying patent without showing any signs of tearing or delamination. Furthermore, stent-grafts fabricated using the methods described here are capable of being implanted using a coronary intervention procedure using standard size guide catheters.

Original languageEnglish (US)
Article numbere54731
JournalJournal of Visualized Experiments
Volume2016
Issue number116
DOIs
StatePublished - Oct 26 2016

Keywords

  • Aneurysm
  • Aortic aneurysm
  • Biomedical engineering
  • Covered stents
  • Endothelialization
  • Extracellular matrix
  • Healing
  • Issue 116
  • Medicine
  • Nanofibers
  • Polyurethane
  • Scaffolds

ASJC Scopus subject areas

  • Neuroscience(all)
  • Chemical Engineering(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

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