F-18 FDG PET scan after radiotherapy for early-stage larynx cancer

Han J. Kim, James Boyd, Frank Dunphy, Val Lowe

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Fluorine-18-fluorodeoxyglucose (F-18 FDG) PET was used to evaluate early-stage larynx cancer before and after radiotherapy. Less radical salvage surgery might be possible after timely diagnosis of recurrent or persistent tumor after radiotherapy. Eight patients with early-stage laryngeal cancer (two carcinoma in situ; six stage T1: tumor limited to vocal cords with normal mobility) underwent irradiation for potential cure. Five patients had pre- and postradiotherapy F-18 FDG PET, and three had postradiotherapy F-18 FDG PET only. All patients underwent a CT scan of the neck at the time of the F-18 FDG PET scan. One patient had a positive result of post-radiotherapy F- 18 FDG PET but a negative result of a CT of the neck, and biopsy revealed recurrent squamous carcinoma. Seven patients who had negative results of postradiotherapy F-18 FDG PET were free of disease at the 15-month median follow-up evaluation. (Three of them had no cancer on biopsy of the larynx, and four others were followed with periodic endoscopic examinations that revealed complete disappearance of the tumor.) F-18 FDG PET scan may be useful for earlier diagnosis of recurrent or persistent laryngeal cancer after radiotherapy and is preferable to repeated biopsies, which would traumatize radiation-damaged tissues. A prompt early diagnosis of failure of radiotherapy will lead to less radical salvage surgery.

Original languageEnglish (US)
Pages (from-to)750-752
Number of pages3
JournalClinical nuclear medicine
Volume23
Issue number11
DOIs
StatePublished - Nov 1 1998

Keywords

  • Larynx
  • Positron Emission Tomography
  • Radiotherapy

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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