Extreme value analysis of gut microbial alterations in colorectal cancer

S. D. Song, P. Jeraldo, J. Chen, Nicholas D Chia

Research output: Contribution to journalArticle

Abstract

Gut microbes play a key role in colorectal carcinogenesis, yet reaching a consensus on microbial signatures remains a challenge. This is in part due to a reliance on mean value estimates. We present an extreme value analysis for overcoming these limitations. By characterizing a power-law fit to the relative abundances of microbes, we capture the same microbial signatures as more complex meta-analyses. Importantly, we show that our method is robust to the variations inherent in microbial community profiling and point to future directions for developing sensitive, reliable analytical methods.

Original languageEnglish (US)
Article number032413
JournalPhysical Review E
Volume99
Issue number3
DOIs
StatePublished - Mar 13 2019

Fingerprint

Colorectal Cancer
Extreme Values
microorganisms
Signature
cancer
signatures
Carcinogenesis
Profiling
Analytical Methods
Mean Value
Power Law
estimates
Estimate
Community

ASJC Scopus subject areas

  • Statistical and Nonlinear Physics
  • Statistics and Probability
  • Condensed Matter Physics

Cite this

Extreme value analysis of gut microbial alterations in colorectal cancer. / Song, S. D.; Jeraldo, P.; Chen, J.; Chia, Nicholas D.

In: Physical Review E, Vol. 99, No. 3, 032413, 13.03.2019.

Research output: Contribution to journalArticle

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