Extranodal Rosai-Dorfman disease involving the heart: Report of two cases

Joseph Maleszewski, Alexandra C. Hristov, Marc K. Halushka, Dylan V. Miller

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease) is a rare disease that typically occurs in lymph nodes. While many body sites have been reported to be involved in extranodal manifestations of the disease, the cardiovascular system has been largely absent in this literature. We report two cases of Rosai-Dorfman disease that involves the heart. Case 1 was a 40-year-old man with chronic myelomonocytic leukemia who was incidentally noted to have Rosai-Dorfman disease on autopsy after succumbing to respiratory failure in the setting of adult respiratory distress syndrome. Case 2 was a 57-year-old woman known to have Rosai-Dorfman disease involving mediastinal lymph nodes and found to have a right atrial mass on workup for atypical chest pain. Both cases showed a similar histologic picture of large, multinucleated histiocytes with immunoreactivity to S100, emperipolesis, and marked plamacytosis. This study expands our knowledge of organs involved in extranodal Rosai-Dorfman disease.

Original languageEnglish (US)
Pages (from-to)380-384
Number of pages5
JournalCardiovascular Pathology
Volume19
Issue number6
DOIs
StatePublished - Nov 1 2010

Fingerprint

Sinus Histiocytosis
Emperipolesis
Lymph Nodes
Leukemia, Myelomonocytic, Chronic
Histiocytes
Adult Respiratory Distress Syndrome
Rare Diseases
Cardiovascular System
Chest Pain
Respiratory Insufficiency
Autopsy

Keywords

  • Cardiac
  • Extranodal
  • Rosai-Dorfman disease
  • Sinus histiocytosis with massive lymphadenopathy

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pathology and Forensic Medicine

Cite this

Extranodal Rosai-Dorfman disease involving the heart : Report of two cases. / Maleszewski, Joseph; Hristov, Alexandra C.; Halushka, Marc K.; Miller, Dylan V.

In: Cardiovascular Pathology, Vol. 19, No. 6, 01.11.2010, p. 380-384.

Research output: Contribution to journalArticle

Maleszewski, Joseph ; Hristov, Alexandra C. ; Halushka, Marc K. ; Miller, Dylan V. / Extranodal Rosai-Dorfman disease involving the heart : Report of two cases. In: Cardiovascular Pathology. 2010 ; Vol. 19, No. 6. pp. 380-384.
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