Extramedullary hematopoiesis manifesting as a symptomatic pleural effusion

R. P. Bartlett, P. R. Greipp, Ayalew Tefferi, R. E. Cupps, B. P. Mullan, V. F. Trastek

Research output: Contribution to journalArticle

76 Citations (Scopus)

Abstract

The occurrence of extramedullary hematopoiesis in the pleura is rare and is usually asymptomatic. It is generally diagnosed on postmortem examination. Herein we describe a 61-year-old woman with agnogenic myeloid metaplasia who sought medical assessment because of progressive dyspnea. Thoracentesis yielded sanguineous fluid with 10% myeloblasts. A 99mTc bone marrow scan demonstrated increased tracer activity throughout both lungs, an outcome consistent with extramedullary hematopoiesis. Fine-needle aspiration and video-assisted thoracoscopy were considered but deferred because of the potential risk of profuse bleeding. Treatment with low-dose external beam irradiation to the left posterior pleura was successful. To date, no hemothorax has recurred.

Original languageEnglish (US)
Pages (from-to)1161-1164
Number of pages4
JournalMayo Clinic Proceedings
Volume70
Issue number12
StatePublished - 1995

Fingerprint

Extramedullary Hematopoiesis
Pleura
Pleural Effusion
Hemothorax
Granulocyte Precursor Cells
Thoracoscopy
Primary Myelofibrosis
Fine Needle Biopsy
Dyspnea
Autopsy
Bone Marrow
Hemorrhage
Lung
Therapeutics
Thoracentesis

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Bartlett, R. P., Greipp, P. R., Tefferi, A., Cupps, R. E., Mullan, B. P., & Trastek, V. F. (1995). Extramedullary hematopoiesis manifesting as a symptomatic pleural effusion. Mayo Clinic Proceedings, 70(12), 1161-1164.

Extramedullary hematopoiesis manifesting as a symptomatic pleural effusion. / Bartlett, R. P.; Greipp, P. R.; Tefferi, Ayalew; Cupps, R. E.; Mullan, B. P.; Trastek, V. F.

In: Mayo Clinic Proceedings, Vol. 70, No. 12, 1995, p. 1161-1164.

Research output: Contribution to journalArticle

Bartlett, RP, Greipp, PR, Tefferi, A, Cupps, RE, Mullan, BP & Trastek, VF 1995, 'Extramedullary hematopoiesis manifesting as a symptomatic pleural effusion', Mayo Clinic Proceedings, vol. 70, no. 12, pp. 1161-1164.
Bartlett RP, Greipp PR, Tefferi A, Cupps RE, Mullan BP, Trastek VF. Extramedullary hematopoiesis manifesting as a symptomatic pleural effusion. Mayo Clinic Proceedings. 1995;70(12):1161-1164.
Bartlett, R. P. ; Greipp, P. R. ; Tefferi, Ayalew ; Cupps, R. E. ; Mullan, B. P. ; Trastek, V. F. / Extramedullary hematopoiesis manifesting as a symptomatic pleural effusion. In: Mayo Clinic Proceedings. 1995 ; Vol. 70, No. 12. pp. 1161-1164.
@article{4fc0a5a5af7544c19a291d4b4e292951,
title = "Extramedullary hematopoiesis manifesting as a symptomatic pleural effusion",
abstract = "The occurrence of extramedullary hematopoiesis in the pleura is rare and is usually asymptomatic. It is generally diagnosed on postmortem examination. Herein we describe a 61-year-old woman with agnogenic myeloid metaplasia who sought medical assessment because of progressive dyspnea. Thoracentesis yielded sanguineous fluid with 10{\%} myeloblasts. A 99mTc bone marrow scan demonstrated increased tracer activity throughout both lungs, an outcome consistent with extramedullary hematopoiesis. Fine-needle aspiration and video-assisted thoracoscopy were considered but deferred because of the potential risk of profuse bleeding. Treatment with low-dose external beam irradiation to the left posterior pleura was successful. To date, no hemothorax has recurred.",
author = "Bartlett, {R. P.} and Greipp, {P. R.} and Ayalew Tefferi and Cupps, {R. E.} and Mullan, {B. P.} and Trastek, {V. F.}",
year = "1995",
language = "English (US)",
volume = "70",
pages = "1161--1164",
journal = "Mayo Clinic Proceedings",
issn = "0025-6196",
publisher = "Elsevier Science",
number = "12",

}

TY - JOUR

T1 - Extramedullary hematopoiesis manifesting as a symptomatic pleural effusion

AU - Bartlett, R. P.

AU - Greipp, P. R.

AU - Tefferi, Ayalew

AU - Cupps, R. E.

AU - Mullan, B. P.

AU - Trastek, V. F.

PY - 1995

Y1 - 1995

N2 - The occurrence of extramedullary hematopoiesis in the pleura is rare and is usually asymptomatic. It is generally diagnosed on postmortem examination. Herein we describe a 61-year-old woman with agnogenic myeloid metaplasia who sought medical assessment because of progressive dyspnea. Thoracentesis yielded sanguineous fluid with 10% myeloblasts. A 99mTc bone marrow scan demonstrated increased tracer activity throughout both lungs, an outcome consistent with extramedullary hematopoiesis. Fine-needle aspiration and video-assisted thoracoscopy were considered but deferred because of the potential risk of profuse bleeding. Treatment with low-dose external beam irradiation to the left posterior pleura was successful. To date, no hemothorax has recurred.

AB - The occurrence of extramedullary hematopoiesis in the pleura is rare and is usually asymptomatic. It is generally diagnosed on postmortem examination. Herein we describe a 61-year-old woman with agnogenic myeloid metaplasia who sought medical assessment because of progressive dyspnea. Thoracentesis yielded sanguineous fluid with 10% myeloblasts. A 99mTc bone marrow scan demonstrated increased tracer activity throughout both lungs, an outcome consistent with extramedullary hematopoiesis. Fine-needle aspiration and video-assisted thoracoscopy were considered but deferred because of the potential risk of profuse bleeding. Treatment with low-dose external beam irradiation to the left posterior pleura was successful. To date, no hemothorax has recurred.

UR - http://www.scopus.com/inward/record.url?scp=0028857978&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028857978&partnerID=8YFLogxK

M3 - Article

VL - 70

SP - 1161

EP - 1164

JO - Mayo Clinic Proceedings

JF - Mayo Clinic Proceedings

SN - 0025-6196

IS - 12

ER -