Extramedullary chronic lymphocytic leukemia: Systematic analysis of cases reported between 1975 and 2012

Megan Ratterman, Kimberly Kruczek, Suela Sulo, Tait D. Shanafelt, Neil E. Kay, Chadi Nabhan

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

The prognostic significance of extra-medullary chronic lymphocytic leukemia (EM-CLL) is unknown. We conducted a Medline database systematic search analyzing English language articles published between 1975 and 2012 identifying 192 cases. Patients with EM-CLL were more commonly treated than not (p<. .001). Skin and central nervous system (CNS) were the most commonly reported sites of organ involvement. Survival after diagnosis of EM-CLL appeared to depend on the site of EM involvement. Prospective evaluation and further studies of EM-CLL are warranted.

Original languageEnglish (US)
Pages (from-to)299-303
Number of pages5
JournalLeukemia Research
Volume38
Issue number3
DOIs
StatePublished - Mar 1 2014

Keywords

  • CLL
  • Chronic lymphocytic leukemia
  • Extra-medullary
  • Prognosis

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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