Extracellular vesicles in the glioblastoma microenvironment: A diagnostic and therapeutic perspective

Marissa N. Russo, Lauren A. Whaley, Emily S. Norton, Natanael Zarco, Hugo Guerrero-Cázares

Research output: Contribution to journalReview articlepeer-review

Abstract

Glioblastoma (GBM), is the most malignant form of gliomas and the most common and lethal primary brain tumor in adults. Conventional cancer treatments have limited to no efficacy on GBM. GBM cells respond and adapt to the surrounding brain parenchyma known as tumor microenvironment (TME) to promote tumor preservation. Among specific TME, there are 3 of particular interest for GBM biology: the perivascular niche, the subventricular zone neurogenic niche, and the immune microenvironment. GBM cells and TME cells present a reciprocal feedback which results in tumor maintenance. One way that these cells can communicate is through extracellular vesicles. These vesicles include exosomes and microvesicles that have the ability to carry both cancerous and non-cancerous cargo, such as miRNA, RNA, proteins, lipids, and DNA. In this review we will discuss the booming topic that is extracellular vesicles, and how they have the novelty to be a diagnostic and targetable vehicle for GBM.

Original languageEnglish (US)
Article number101167
JournalMolecular Aspects of Medicine
Volume91
DOIs
StateAccepted/In press - 2022

Keywords

  • Exosomes
  • Glioblastoma multiforme
  • Microvesicles
  • Perivascular niche
  • Subventricular zone/neurogenic niche
  • Tumor microenvironment

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Clinical Biochemistry

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