Extracellular vesicles in liver diseases

Sayantan Maji; Akiko Matsuda; Irene K. Yan; Mansi Parasramka; Tushar Patel

doi:10.1152/ajpgi.00216.2016

Extracellular vesicles in liver diseases

Sayantan Maji, Akiko Matsuda, Irene K. Yan, Mansi Parasramka, Tushar Patel

Gastroenterology and Hepatology

Research output: Contribution to journal › Review article › peer-review

23 Scopus citations

Abstract

Extracellular vesicles (EVs) are membrane-bound vesicles that are released by cells into their extracellular environment, have selective enrichment of specific proteins and RNA, and can mediate intercellular communication. In this review we highlight recent observations of the role of EVs in liver injury, viral hepatitis, alcoholic or nonalcoholic liver disease, biliary tract disease, and liver cancers. Potential applications as markers of diseases or for therapeutic applications are outlined to emphasize the new opportunities that are arising from the study of EVs.

Original language	English (US)
Pages (from-to)	G194-G200
Journal	American Journal of Physiology - Gastrointestinal and Liver Physiology
Volume	312
Issue number	3
DOIs	https://doi.org/10.1152/ajpgi.00216.2016
State	Published - Mar 2017

Keywords

Cancer
Extracellular vesicles
Liver diseases
MicroRNA

ASJC Scopus subject areas

Physiology
Hepatology
Gastroenterology
Physiology (medical)

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10.1152/ajpgi.00216.2016

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title = "Extracellular vesicles in liver diseases",

abstract = "Extracellular vesicles (EVs) are membrane-bound vesicles that are released by cells into their extracellular environment, have selective enrichment of specific proteins and RNA, and can mediate intercellular communication. In this review we highlight recent observations of the role of EVs in liver injury, viral hepatitis, alcoholic or nonalcoholic liver disease, biliary tract disease, and liver cancers. Potential applications as markers of diseases or for therapeutic applications are outlined to emphasize the new opportunities that are arising from the study of EVs.",

keywords = "Cancer, Extracellular vesicles, Liver diseases, MicroRNA",

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AU - Maji, Sayantan

AU - Matsuda, Akiko

AU - Yan, Irene K.

AU - Parasramka, Mansi

AU - Patel, Tushar

PY - 2017/3

Y1 - 2017/3

N2 - Extracellular vesicles (EVs) are membrane-bound vesicles that are released by cells into their extracellular environment, have selective enrichment of specific proteins and RNA, and can mediate intercellular communication. In this review we highlight recent observations of the role of EVs in liver injury, viral hepatitis, alcoholic or nonalcoholic liver disease, biliary tract disease, and liver cancers. Potential applications as markers of diseases or for therapeutic applications are outlined to emphasize the new opportunities that are arising from the study of EVs.

AB - Extracellular vesicles (EVs) are membrane-bound vesicles that are released by cells into their extracellular environment, have selective enrichment of specific proteins and RNA, and can mediate intercellular communication. In this review we highlight recent observations of the role of EVs in liver injury, viral hepatitis, alcoholic or nonalcoholic liver disease, biliary tract disease, and liver cancers. Potential applications as markers of diseases or for therapeutic applications are outlined to emphasize the new opportunities that are arising from the study of EVs.

KW - Cancer

KW - Extracellular vesicles

KW - Liver diseases

KW - MicroRNA

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Extracellular vesicles in liver diseases

Abstract

Keywords

ASJC Scopus subject areas

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