Extracellular vesicles in liver diseases

Sayantan Maji, Akiko Matsuda, Irene K. Yan, Mansi Parasramka, Tushar Patel

Research output: Contribution to journalReview article

20 Scopus citations

Abstract

Extracellular vesicles (EVs) are membrane-bound vesicles that are released by cells into their extracellular environment, have selective enrichment of specific proteins and RNA, and can mediate intercellular communication. In this review we highlight recent observations of the role of EVs in liver injury, viral hepatitis, alcoholic or nonalcoholic liver disease, biliary tract disease, and liver cancers. Potential applications as markers of diseases or for therapeutic applications are outlined to emphasize the new opportunities that are arising from the study of EVs.

Original languageEnglish (US)
Pages (from-to)G194-G200
JournalAmerican Journal of Physiology - Gastrointestinal and Liver Physiology
Volume312
Issue number3
DOIs
StatePublished - Mar 2017

Keywords

  • Cancer
  • Extracellular vesicles
  • Liver diseases
  • MicroRNA

ASJC Scopus subject areas

  • Physiology
  • Hepatology
  • Gastroenterology
  • Physiology (medical)

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